干燥法长期保存角膜片板层治疗性角膜移植1267例临床研究(英文)  

Clinical Study on 1267 Cases of Lamellar Therapeutic Keratoplasty Using Dehydrated Corneal Grafts in Long-time Storage

作　　者：朱秀萍 张长宁 吴洁 马挺 朱斌良 刘景堂 银勇 刘先宁 杨问学 

机构地区：[1]中国西安市眼科医院西安市眼科研究所,710002

出　　处：《美中国际眼科杂志》2002年第4期11-14,共4页

摘　　要：目的评价干燥脱水法长期保存角膜片在板层治疗性角膜移植术中的效果。方法保存角膜片选自我院眼库干燥保存符合临床标准、复水透明的完整角膜片,临床病例选自我院角膜病组1976年8月～1999年12月期间行板层治疗性角膜移植患者1267例,从手术前后观力比较、原发病灶控制、植片存活情况进行临床效果综合分析。结果保存角膜片复水透明合格率为94.9％,临床治愈率:感染性角膜溃疡/穿孔88.8％,血管翳性全角膜白班98.3％.化学及热烧伤(穿孔,睑球角粘连等)92.1％,圆锥角膜及急性圆锥角膜99.5%,角膜变性(边缘性及前基质层)99.0％,其他88.9%,平均总治愈率93.5％。结论①对各种严重的角膜感染、药物治疗无法控制的患者,治疗性角膜移植术是唯一有效的方法。②采用无水氯化钙-硅胶干燥脱水长期保存的供体角膜能为临床随时提供角膜材料,是一项简单易行、便于推广应用的成功率很高的保存方法。Abstract Objective To evaluate 1267 cases of therapeutic keratoplasty using dehydrated rorneal grafts in long-time storage. Methods The corneal grafts had been stored in Xi'an Eye Bank and they conformed to the clinical demands. A total of 1267 cases of therapeutic keratoplasty performed in our hospital between Aug. 1976 to Dec. 1999 were analysed in the way of preoperational and postoperational vision, control of original focuses, and survival of corneal grafts. Results The transparent rate of corneal grafts after preservation was 94.9%; the clinical cure rate was respectively 88.8% in infective corneal ulcer/perforation, 98.3% in pannus totalis and corneal opacity, 92.1% in chemical burns and heat burns (perforation, corneohlepharon), 99.5% in keratoconus and acute kerato-conus, 99.0% in corneal degeneration(marginal, shallow of stroma) and 88.9% in other cases, the mean cure rate being 93.5%. Conclusion ① In cases of serious corneal infection which respond to medicine poorly, therapeutic keratoplasty may he the only effective method. ②Corneal grafts stored in water-free calcium chloride-silica gel for long time is available for clinical use at anytime, and the storage is easy, simple and highly applicable.

关 键 词：板层角膜移植 干燥脱水法 保存 角膜片 

分 类 号：R779.65[医药卫生—眼科]