贲门癌组织中P-糖蛋白和p53蛋白的表达及其意义  

Expression and Significance of P-glycoprotein and p53 Protein in Gastric Cardiac Carcinoma

作　　者：刘祖宏[1] 谢丽霞[1] 许文兵[1] 

机构地区：[1]广东揭阳市人民医院病理科,522000

出　　处：《实用癌症杂志》2003年第1期52-53,58,共3页The Practical Journal of Cancer

摘　　要：目的　探讨贲门癌组织中P -糖蛋白 (p -gp)和p5 3蛋白共同表达的临床意义 ,研究其与贲门癌生物学行为的关系。方法　采用免疫组化方法 (二步法 )检测 66例术前未经化疗的贲门癌组织中多药耐药基因产物P -糖蛋白和 p5 3蛋白的表达情况。结果　P -gp和 p5 3在贲门癌组织中表达率分别为 3 6.4% (2 4/66)和 5 1.5 % (3 4/66)。P -gp表达与贲门癌组织学类型、临床分期和淋巴结转移均无关 (P >0 .0 5 ) ;p5 3除与淋巴结转移有关外 (P <0 .0 5 ) ,与其组织学类型和临床分期均无关 (P >0 .0 5 )。p5 3表达阳性病例P -gp表达率明显高于 p5 3表达阴性病例 ,即 83 .3 %P -gp阳性表达患者 p5 3表达阳性。 结论　P -gp和 p5 3常共同表达于贲门癌组织中 ,可作为判断贲门癌患者预后和临床耐药的Objective To investigate the significance of coordinated expression of P glycoprotein and p53 protein in gastric cardiac carcinoma and the correlation of the expression with the biological behavior of cardiac carcinoma.Methods The expressions of multidrug resistance gene product P glycoprotein and p53 protein were determined by immunohistochemical method(two step method) in 66 patients with gastric cardiac carcinoma that didn't receive chemotherapy before operation.Results The positive rate of P glycoprotein and p53 protein expression in gastric cardiac carcinoma was 36.4%(24/66) and 51.5%(34/66) respectively.There were not significant differences in level of P glycoprotein in different histopathological types,clinical stages and rates of lymph node metastases( P >0.05).Except the rate of lymph node metastases( P <0.05),p53 protein expression did not correlate with histopathological type and clinical stage( P >0.05).P glycoprotein expression was significantly higher in p53 positive cases than in p53 negative cases,83.3% of P glycoprotein positive tumors was also p53 protein positive.Conclusion There are common expression of P glycoprotein and p53 protein in gastric cardiac carcinoma tissue,and it may be taken as a reliable criteria to judge the prognosis and multidrug resistance.

关 键 词：贲门癌 P-糖蛋白 P53蛋白 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]