肝炎后肝硬化患者血浆内毒素、白介素-6和白介素-8水平的研究  

Testing of Endotoxin,Interleukin-6 and Interleukin-8 in Patients with Cirrhosis

作　　者：吴达军[1] 曾皓[1] 刘俊[1] 

机构地区：[1]江西医学院第一附属医院消化内科,江西南昌330006

出　　处：《实用临床医学（江西）》2003年第1期31-32,39,共3页Practical Clinical Medicine

摘　　要：目的 :探讨内素毒素、IL 6、IL 8水平与门脉高压的关系 ,揭示内毒素、IL 6、IL 8在肝炎后肝硬化发病机制中的作用。方法 :采用鲎试剂与合成基质 (鲎三肽 )的偶氮显色法和ELISA法分别检测患者血浆内毒素、IL 6、IL 8水平。结果 :肝硬化组血浆内毒素、IL 6、IL 8水平均高于正常对照组 (P <0 .0 0 1) ;相关性分析二者间呈正相关 ;肝硬化组按Child pugh分级后 ,血浆内毒素、IL 6、IL 8含量由高到低依次为Child C级、B级、A级组。结论 :内毒素、L 6、IL 8肝炎后肝硬化的发生与发展中起重要作用 ,且参与了门脉高压的形成并维持其存在。Objective:To explore the relationship of the levels of plasma endotoxin, interleukin 6(IL 6),and interleukn 8(IL 8)with pathogenesis in patients with cirrhosis due to HBV Hepatitis.Methods: Levels of plasma endotoxin,IL 6 and IL 8 were detectec by limulus assay and ELISA respectively in 64 patients and 20 controls.Results:Endotoxin, IL 6 and IL 8 levels were higher in the patients than those in controls( P <0.001). There were significant correlations among endotoxin,IL 6 and IL 8 levers.Endotoxin, IL 6 and IL 8 levels in cirrhosis increased with worsening of Child score.Conclusion:Endotoxin,IL 6 and IL 6 may play important roles in the pathogenetic process of the cirrhosis.Endotoxin,IL 6 and IL 8 may participate in the development and/or maintenance of hyperdynmic circulation and portal hypertension.

关 键 词：内毒素 白介素-6 白介素-8 肝硬化 门脉高压 

分 类 号：R575.2[医药卫生—消化系统]