骨转移瘤患者骨密度和血清骨代谢指标变化的临床研究  

CLINICAL RESEARCH ON THE VARIANCE OF BONE MINERAL DENSITY AND BONE METABOLISM OF CARCINOMA PATIENTS WITH BONE MATASTASIS

作　　者：孙达春[1] 张爱华[1] 李小亮[1] 吴红[1] 汪丽安[1] 赵玉成[1] 

机构地区：[1]珠海市人民医院

出　　处：《肿瘤研究与临床》2003年第1期16-18,共3页Cancer Research and Clinic

基　　金：珠海市科研基金资助项目 ( 2 0 0 14 1)

摘　　要：目的 :研究骨转移瘤患者骨密度和骨代谢状态的变化。方法 :采用双能 X线骨密度仪(DEXA)测量 2 0例骨转移瘤患者骨密度 (BMD) ,同时采用放射免疫法测定血清骨钙素 (BGP) , 型胶原羧基末端肽 (ICTP)水平 ,并与 2 0例正常人作对照。结果 :骨转移瘤组 L2 、L3、L4,右股骨颈 ,右Ward区和右大转子 BMD显著下降 (P<0 .0 5～ P<0 .0 0 1)。骨转移瘤组血清 BGP、ICTP显著升高 (P<0 .0 5～ P<0 .0 0 1)。结论 :骨转移瘤患者腰椎、髋部 BMD下降 ,血清 BGP、ICTP升高 ,骨转换增快。Objective:To investigate the variance of bone meineral,density and bone metabolism of carcinoma patients with bone metastasis.Methods:Double energy X-ray absorptiometry (DEXA) was employed to detect the bone mineral density (BMD) of carcinoma patients with bone metastasis,and blood serum Osteocalcin (BFP) and serum carboxy-terminal collagen telopeptide (ICTP) of 20 healthy control were assayed by radio-immunity.Results:In carcinoma patients with bone metastasis group L2,L3,L4,BMD of right neck of femur and right ward region decreased significantly (P<0.05～P<0.001).BGP,ICTP increased significantly (P<0.05～P<0.01) in carcinoma patients with bone metastasiss group.Conclusion:In carcinoma patients with bone mtetastasis the BMP of lumbar vertebra and hip decreased,while the serum BGP and ICTP increased significantly (P<0.05～P<0.01).The transforming of bone was accelerated.

关 键 词：骨转移瘤 骨密度 骨钙素 Ⅰ型胶原羧基末端肽 

分 类 号：R735.1[医药卫生—肿瘤]