血清C反应蛋白升高与慢性脑供血不足风险关系的病例对照研究  

Association of serum C-reactive protein with prevalence of chronic cerebral circulation insufficiency:a case-control study

作　　者：庞秀宇 李雪[1] 庞秀明[3] 庞秀玉 李颖[1] 姜昆 

机构地区：[1]哈尔滨医科大学公共卫生学院营养与食品卫生教研室,黑龙江哈尔滨150081 [2]黑龙江中医药科学院神经电生理科,黑龙江哈尔滨150036 [3]黑龙江中医药大学附属第二医院跃进社区卫生服务中心,黑龙江哈尔滨150000 [4]黑龙江省民政慈善医院心血管内科,黑龙江哈尔滨150030

出　　处：《中华疾病控制杂志》2015年第6期551-554,共4页Chinese Journal of Disease Control & Prevention

基　　金：黑龙江省高校长江学者后备支持计划项目(2012CJHB006)

摘　　要：目的探讨血清C反应蛋白(C-reactive protein,CRP)与慢性脑供血不足(chronic cerebral circulation insufficiency,CCCI)的相关性。方法纳入黑龙江省中医院门诊确诊的新发病例142例,正常对照组142例。该病例对照研究将年龄、性别作为匹配因素进行1∶1个体匹配,比较病例组、对照组CRP水平的组间差异;将CRP水平四分位分组,采用条件Logistic回归分析相对危险度。结果病例组的CRP水平高于对照组(Z=-3.69,P<0.001);在校正了多种混杂因素之后,结果表明血清CRP水平最高四分位组的CCCI患病风险是低水平组的3.08倍(OR=3.08,95%CI:1.27~7.46)。结论血清CRP升高与CCCI患病风险之间可能存在相关性。Objective To investigate the correlation between serum C-reactive protein( CRP) and prevalence of chronic cerebral insufficiency( CCCI).Methods The case-control study included 142 current CCCI patients,and 142 subjects without CCCI as control.The study was based on the clinical data at Heilongjiang University of Chinese Medicine.Controls were 1:1 matched to each patient in terms of age and sex.The CRP levels were compared between cases and controls.According to the quartiles of CRP,conditional Logistic regression was used to analyze the relative risk of CCCI.Results Serum CRP levels in patients with CCCI were significantly higher than that in controls( Z =-3.69,P < 0.001).Subjects in the highest quartile of CRP levels were at a high risk of CCCI by 3.08 times than those in the lowest quartile after adjustment for multiple confounding factors.( OR = 3.08,95% CI:1.27-7.46).Conclusions High levels of serum CRP may correlate with the high risk of CCCI.

关 键 词：C反应蛋白质 病例对照研究 流行病学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]