肥城市食管癌的危险因素研究  

Study on Risk Factors of Esophageal Cancer in Feicheng City

作　　者：赵德利[1] 杨友德[1] 陈明会[1] 胡茂新[1] 张泉河[1] 郭晓路[1] 李会庆[2] 金世宽[2] 

机构地区：[1]肥城市人民医院(山东省肿瘤防治研究基地),山东肥城271600 [2]山东省医学科学院基础医学研究所,山东济南250012

出　　处：《肿瘤防治杂志》2003年第1期27-30,共4页China Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨肥城市食管癌高发的危险因素。方法:采用病例对照研究方法,问卷调查获取资料,分层分析和Logistic回归分析计算统计指标OR。结果:185例患者和204例对照,在调整的因素为年龄、性别、文化水平、吸烟指数、饮酒指数和喝茶指数等因素后,发现食管癌家族史、患有食管病史、吃咸菜多、吃霉变食品、种菜少或不种菜、水源污染为危险因素。对10年前和20年前的饮食组成和营养成分分析发现,居民10年前和20年前的大豆及豆制品摄入量对照组是病例组的2倍。将其按所含的营养成分计算后两组比较,20年前蛋白、铁、磷摄入量多有保护性作用,并呈线形相关。不同因素共同暴露分析显示,食管癌家族史与食管病史、吸烟和饮酒有协同作用,蛋白摄入量增加有拮抗作用。结论:本地区食管癌危险因素的特异性发现为水源污染和蛋白摄入量偏低,大豆蛋白可能有保护作用。Objective To explore the rist factors of esophagus cancer in Feicheng city, Shandong. Methods A case-control study was carried out and the data were analysed by strata and Logistic regressin. Results After adjusted confounders such as age,sex,education,smoke,drinking alcohol and tea, the rist factors were history of family esophagus cancer, suffering esophagus illness, eating salted vegetable or moulds foods, growing small or no-growing vegetable, water pollution. While analysing the consitution of foods or nutrition before 10 or 20 years, the consume of soybean in control group was two times more than those in case group, and more protein, iron and phosphate taken were negative association with the cancer. The results of two different rist factors combining analyzed showed there were syntheses effects between history of family esophagus cancer and esophagus disease,or between smoking and drinking,or low protein foods consumed. Conclusions The special risk factors in the area may be water pollution, low protein taken. Also eating more soybean may have protective effect against esophagus cancer.

关 键 词：食管肿瘤 危险因素 病例对照研究 

分 类 号：R735.1[医药卫生—肿瘤]