豫医无毛小鼠寿命观察  

Investigation on life span of Yuyi hairless mice

作　　者：杜春燕[1] 李洪涛[1] 章金涛[1] 王纯耀[1] 杜献堂[2] 

机构地区：[1]河南省实验动物中心,郑州450052 [2]郑州大学基础医学院微生物学与免疫学教研学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2003年第2期196-198,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省医学科技创新人才工程资助项目2 0 0 10 90 7

摘　　要：目的 :通过对豫医无毛小鼠寿命的观察 ,探讨突变基因对无毛小鼠寿命的影响。方法 :在正常生产繁殖状态下 ,随机选取无毛小鼠雌雄各 50只 ,杂合子有毛小鼠雌雄各 2 5只 ,饲养条件、营养状况、实验方法等均相同 ,观察每只小鼠自然衰老的过程 ,并计算出各自的寿命。结果 :纯合子无毛小鼠平均寿命雌性为 (30 3 .3± 35 .0 )d、雄性为 (2 61 .6± 41 .2 )d ,杂合子有毛小鼠平均寿命雌性为 (382 .7± 35 .7)d、雄性为 (353 .0± 37.2 )d。纯合子无毛小鼠与杂合子同性别有毛小鼠寿命相比差异有统计学意义 (P <0 .0 1 )。结论 :突变基因可能对无毛小鼠的寿命有影响 。Aim:To observe how the mutation gene affects life span of inbred strain Yuyi hairless mice. Methods:Hairless mice (50 males and 50 females) and heterozygous hairy mice (25 males and 25 females) under the same condition of feeding and nutrition were randomly selected.Life span of each mouse was calculated. Results: Average life span of hemozygous hairless mice were (303.3±35.0) d for female and (261.6±41.2) d for male, and those of heterozygous mice were ( 382.7± 35.7) d for female and (353.0±37.2) d for male, and there was significant difference between 2 groups for the same sex ( P < 0.01). Conclusion: The effects of mutation gene on life span of hairless mice is significant.

关 键 词：统计学分析 基因突变 小鼠 寿命 

分 类 号：Q344.12[生物学—遗传学]