大剂量甲氨蝶呤治疗急性淋巴细胞白血病耐受性观察  

Tolerability of acute lymphocytic leukemia(ALL) treated by HD-MTX

作　　者：孙杰[1] 岳玉[1] 张斌[1] 

机构地区：[1]安徽省蚌埠市第一人民医院肿瘤内科,233000

出　　处：《淮海医药》2003年第2期88-89,共2页Journal of Huaihai Medicine

摘　　要：目的　探讨大剂量甲氨蝶呤 ( HD- MTX 3～ 5 g/ m2 )连续 2 4h静脉输注 ,第 3 6h甲酰四氢叶酸钙( CF)解救治疗急性淋巴细胞白血病的临床耐受性。方法　 8例急性淋巴细胞白血病缓解期患者共进行 16个疗程大剂量 MTX 3～ 5 g/ m2 化疗 ,连续 2 4h静脉输注 ,第 3 6小时 CF解救。结果　不良反应 :恶心呕吐、中性粒细胞减少和一过性转氨酶升高为 °～ °,口腔粘膜毒性 °～ °,无严重毒副反应发生。结论　大剂量 MTX3～ 5 g/ m2连续 2 4h静脉输注 ,第 3 6小时Objective To study the tolerabillity of HD-MTX(3～5 g/m 2)for 24 h continously followed by rescue with CF at the 36th hour.Methods Eight cases of ALL were respectively given total 16 times of HD-MTX (3～5 g/m 2)for 24 h continously and rescued with CF at the 36th hour.Results The side-effects were nausea,vomiting,neutropenie and mild increase of transaminase,mucositis.There was no severe side effect.Conclusion The method of HD-MTX(3～5 g/m 2) continuous infusion for 24 hours followed by rescue with CF at the 36th hour is a tolerabale and safe regimen for the treatment of ALL.

关 键 词：剂量 甲氨蝶呤 治疗 急性淋巴细胞白血病 耐受性 

分 类 号：R733.71[医药卫生—肿瘤]