肿瘤坏死因子在儿童中枢神经系统感染中的临床意义  

Clinical Significance of Tumor Necrosis Factor in Children's Infection of Central Nervous System

作　　者：杨宝昌[1] 潘春莹[1] 黄敬孚[1] 许辉[1] 

机构地区：[1]天津市儿童医院内科,300074

出　　处：《天津医药》2003年第3期154-155,共2页Tianjin Medical Journal

摘　　要：目的 :探讨急性中枢神经系统感染的儿童血清和脑脊液中肿瘤坏死因子(TNF)水平的变化及临床意义。方法 :采用ELISA法测定颅内感染患儿 ,其中细菌性脑膜炎组(化脑组)20例 ,病毒性脑炎组(病脑组)22例 ,对照组16例。结果 :化脑组血清和脑脊液TNF水平(μg/L)分别为0.236±0.105、0.211±0.094 ,明显高于病脑组0.125±0.039、0.109±0.032和对照组0.125±0.039、0.109±0.032 ,其差别具有显著性意义 ;病脑组TNF水平亦明显高于对照组。将化脑组血清和脑脊液的TNF水平进行相关性分析(r=0.935,t=7.67,P<0.01)呈正相关。结论 :脑脊液TNF的水平可以作为细菌性脑膜炎的诊断指标 ,血液和脑脊液的TNF水平对鉴别细菌性和病毒性颅内感染有重要的意义 ;在病理情况下血液的TNF水平可以反映脑脊液TNF的变化 。Objective:To study the clinical significance of tumor necrosis factor(TNF)in children's infection of central nervous system.Methods:TNF in serum and cerebrospinal fluid(CSF)was determined with ELISA in42children with acute infection central nervous system,among them there were20cases with germs meningitis and22cases with virus meingitis or encephalitis.Sixteen healthy children served as controls.Results:The levels of TNF of germs meningitis group in serum(0.236±0.105μg/L)and in CSF(0.211±0.094μg/L)were markedly higher than those of virus meningitis group in serum(0.125±0.030μg/L)and in CSF(0.109±0.032μg/L)and those of control group in serum(0.125±0.039μg/L)and in CSF(0.109±0.032μg/L).The TNF level in virus encephalitis group was obviously higher than that in control group.In germs meningitis group,a significant correlation was observed between the levels of TNF in serum and CSF(r=0.935,t=7.67,P<0.01).Conclusion:The level of TNF in CSF can be used as an important index for the bacterial meningitis's diagnosis.The levels of TNF in serumn and CSF were of important significance for differential diagnosis of bacterial menigitis and virus meningitis.In pathologic state,the level of TNF in serumn can reflect the variety of TNF level in CSF and can provide a basis for clinical application of anti-TNF antibody in infectious disease.

关 键 词：肿瘤坏死因子 儿童 中枢神经系统感染 临床意义 

分 类 号：R741[医药卫生—神经病学与精神病学]