薏苡仁酯和平阳霉素抑制鼻咽癌细胞增殖的相互作用  

The Interaction Between Coixenolide and Pingyangmycin in Inhibiting the Proliferation of Human Nasopharygeal Carcinoma Cells

作　　者：陈宁[1] 李毓[1] 熊带水[1] 

机构地区：[1]广东省中医研究所,广东广州510095

出　　处：《华夏医学》2003年第1期11-13,共3页Acta Medicinae Sinica

基　　金：广东省中医药管理局资助项目 ( No.972 66)

摘　　要：目的 :探讨薏苡仁酯 (coixenolide,CXL)和平阳霉素 (pingyangmycin,PYM)抑制人鼻咽癌细胞 CNE- 2 Z增殖的联合效应。方法 :采用微量细胞克隆形成法检测 CNE- 2 Z的增殖能力和对药物的敏感性。结果 :CXL和 PYM均以量效方式抑制 CNE- 2 Z细胞的克隆形成 ,ID50 分别是 10 - 4.758mol/ L 和 10 - 5.4 94 mol/ L。将 CXL 和 PYM以 4∶ 1的剂量 (摩尔浓度 )比合用 ,全部效应协同。两药 5∶ 1,抑制率≤ 5 0 %时 ,协同 ;=6 0 % ,相加 ;≥ 70 % ,拮抗。 6∶ 1,抑制率 =10 %时 ,协同 ;≥ 2 0 % ,拮抗。结论 :CXL和 PYM的相互作用可产生多种联合效应 ,与合用的剂量。Objective: To study the combined effects of coixenolide (CXL) and pingyangmycin (PYM) in suppressing the generation of human nasopharygeal carcinoma cell line CNE 2Z Methods: Microcolony formation assay was used in determing the sensitivity of CNE 2Z to the two drugs Results: CXL and PYM dose dependently depressed the CNE 2Z colony formation, with ID 50 =10 4 758 mol/L and 10 5 494 mol/L, respectively Combination of CXL with PYM in a dose (molar concentration) ratio of 4∶1 showed synergism at various effect levels In 5∶1, displayed synergism at inhibitory rate ≤50%;additivism at 60%; antagonism at ≥70% In 6∶1, exhibited synergism at 10%; antagonism at ≥20% Conclusion: The interaction of the two drugs produces the different combined effects, which is closely related to the dose and dose ratios

关 键 词：薏苡仁酯 平阳霉素 联合效应 鼻咽肿瘤 

分 类 号：R739.63[医药卫生—肿瘤] R979.1[医药卫生—临床医学]