三类恶性肿瘤患者血清唾液酸的检测及其临床意义  

Detection of serum sialic acid in three kinds of malignant tumor and its clinical significance

作　　者：梁湘辉[1] 梁贤明[1] 易斌[1] 徐淑兰[1] 

机构地区：[1]中南大学湘雅医院检验科,长沙410008

出　　处：《湖南医科大学学报》2003年第1期65-66,共2页Bulletin of Hunan Medical University

摘　　要：目的 :探讨检测血清唾液酸对三类恶性肿瘤的诊断及预后的价值。方法 :对健康人 (对照组 ) 10 0例 ,三类恶性肿瘤患者 72例 (其中肺癌 37例 ;急性白血病 2 8例 ;直肠癌 17例 )检测其血清唾液酸 (SA)水平并进行统计学分析。结果 :三类恶性肿瘤患者血清SA水平治疗前、后较对照组明显升高 (均 P<0 .0 5 ) ;治疗前 ,肺癌、急性白血病、直肠癌血清SA阳性率分别为 84 % ,79% ,71% ;治疗后病情好转者 ,其血清SA水平明显下降 (均P <0 .0 0 1) ;而恶化死亡者血清SA水平均无降低。结论 :检测血清SA含量对三类恶性肿瘤有一定的诊断价值 。Objective To study the diagnostic significance and clinical effect of the detection of serum sialic acid (SA) in three kinds of malignant tumor. Methods The specimens (172) were divided into the healthy control group (100), lung cancer group (31), leukemia group (28) and rectual cancer group (17), and then the serum SA concentration in those specimens was analyzed and statistic analysis was conducted. Results The SA levels of the malignant tumor groups before and after the treatment were significantly higher than those of the healthy control group (P<0.05). The positive rates of serum SA in the lung cancer group, leukemia group and rectual group were 84%, 79% and 71%. Conclusion The SA concentration was significantly increased in the malignant patients so SA can be used as an indication of cancer, and it can be widely used in the diagnosis and inspection of malignant tumor.

关 键 词：唾液酸类 恶性肿瘤 诊断 

分 类 号：R730.43[医药卫生—肿瘤]