BALB/C小鼠免疫耐受模型建立及移植人体肺癌初步研究  

ESTABLISHMENT OF IMMUNE TOLERANCE MODEL IN BALB/C MOUSE AND PRELIMINARY STUDY ON THE TRANSPLANTING HUMAN LUNG CANCER

作　　者：任金荣[1] 郑振海 王增林[1] 刘鹿宁[1] 于凤玲[1] 

机构地区：[1]河北医科大学第四医院河北省肿瘤研究所,河北石家庄050011 [2]河北灵寿郑氏生物癌研究所,河北灵寿县050500

出　　处：《癌变．畸变．突变》2003年第1期25-27,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的 :获得一种能移植人体肿瘤并存活的动物模型。 方法 :将郑氏植物蛋白(ZPP)0.1ml皮下注射BALB/C小鼠 ,诱导其免疫耐受并移植人体肺肿瘤组织。 结果 :移植肺肿瘤在模型动物体内存活 ,成功率可达65 %(26/40) ,而对照组小鼠体内移植瘤全部被排斥 ,不能存活。 结论 :ZPP可引起小鼠对人体肺肿瘤细胞免疫耐受 ,使移植瘤成活。Purpose: To obtain an animal model in which the human lung tumor may successfully be transplanted and survival. Methods: In new born BALB / C mice the immune tolerance was induced by injecting Zheng's plant_protein (ZPP), and then the human lung tumor tissues were transplanted into the mice. Results: 65 % (26 / 40) of the transplanted human lung tumor tissues were survival whereas in the control mice the transplanted tumors were totally rejected. Conclusion: ZPP may induce immune tolerance in BALB / C mouse and the transplanted human lung cancer may be survival in the mouse. [

关 键 词：BALB/C小鼠 免疫耐受 肺肿瘤 移植 郑氏植物蛋白 

分 类 号：R73－35[医药卫生—肿瘤]