晚期头颈恶性肿瘤组织含促血小板聚集物  

The Substance Aggregating Platelets Derived from Advanced Malignant Tumor of Head and Neck

作　　者：黄光武[1] 曾钢[1] 余奇松[1] NongHuitu 农辉图[1] 砂川昌范[2] 小杉忠诚[2] 邝国乾[3] 

机构地区：[1]广西医科大学耳鼻喉科,南宁市滨湖路6号530021 [2]日本琉球大学医学部生理学 [3]广西医科大学附属肿瘤医院

出　　处：《广西科学》2003年第1期47-51,共5页Guangxi Sciences

基　　金：国家教育部优秀青年教师基金课题。

摘　　要：为探讨头颈恶性肿瘤组织提取液是否含有聚集血小板的物质,将15例头颈恶性肿瘤和14例非恶性肿瘤组织匀浆取组织提取液,分别致聚于头颈恶性肿瘤21例.非肿瘤、非恶性肿瘤33例及健康人16例的血小板。发现,头颈恶性肿瘤组织提取液致聚的阳性率比非恶性头颈肿瘤组织提取液致聚的高;头颈恶性肿瘤组织提取液对血小板的聚集作用随病期进展而增强;头颈部恶性肿瘤病人的血小板易受组织提取液激聚,其血小板最大聚集率随病期进展而增强。表明,晚期头颈恶性肿瘤组织含促血小板聚集物,这可能是直接引起恶性肿瘤机体血小板聚集增强的原因之一。To explore whether the substance aggregating platelets are contained in the extraction of malignant tumor tissue of head and neck,the tumor tissue from 15 cases of malignant tumor and 14 cases of nonmalignant tumor in head and neck are homogenized as crude extraction,which are found to aggregate platelets in 21 cases of malignant tumor, 33 cases of non-tumor and nonmalignant tumor of head and neck, and 16 controls respectively. The positive rate of aggregation induced by extraction from malignant tumor is higher than that from nonmalignant tumor; the aggregating function induced by extraction from the malignant increases with disease developing;the platelets of the cases in the malignant tumor group are apt to be aggregated by the crude extraction of tumor tissue, in which the maximum aggregation rate of platelets increases with disease developing. It is suggested that the aggregation substance is contained in the tissue of advanced malignant tumor of head and neck, and the aggregating substance from malignant tumor might directly affect the function of platelets in circulation of blood.

关 键 词：头颈肿瘤 血小板聚集 肿瘤提取液 恶性肿瘤 肿瘤组织 

分 类 号：R739.91[医药卫生—肿瘤]