血管内皮生长因子和抑癌基因p53在胃癌中的表达及其临床意义  

Clinical significance of vascular endothelial growth factor and p53 gene expression in human gastric cancer

作　　者：周烨[1] 朱慰祺[1] 师英强[1] 施达仁[2] 

机构地区：[1]复旦大学附属肿瘤医院腹外科,上海200032 [2]复旦大学附属肿瘤医院病理科,上海200032

出　　处：《中国癌症杂志》2003年第1期9-12,共4页China Oncology

摘　　要：目的 :研究血管内皮生长因子 (vascularendothelialgrowthfactor,VEGF)和抑癌基因p53表达的的相关性 ,与胃癌临床病理学指标的关系及其联合表达对胃癌患者预后的影响。方法 :应用免疫组化法同时检测 1 0 8例胃癌组织VEGF和P53蛋白表达水平。结果 :本组病例VEGF蛋白表达阳性率为 53 .7% ,P53蛋白表达阳性率为 57.4 % ,且两者呈正相关 (P <0 .0 1 )。VEGF蛋白表达水平与浆膜浸润、淋巴结转移和TNM分期有关 (P <0 .0 1 )。P53蛋白表达水平与患者年龄、肿瘤部位、脉管侵犯、浆膜浸润、淋巴结转移和TNM分期有关 (P <0 .0 5)。并且两者的表达和胃癌患者的预后呈负相关 (P <0 .0 1 )。结论 :VEGF和P53蛋白的表达呈正相关和胃癌的生物学特性有关 。Purpose:To investigate the association between the expression of vascular endothelial growth factor (VEGF) and p53, and their influence on clinicopathological characteristics and prognostic value in gastric cancer.Methods:A total of 108 paraffin embedded gastric cancer tissues were stained with the monoclonal antibodies VEGF and P53 protein by immunohistochemistry.Results:VEGF and P53 expression were observed in 53.7% and 57.4% of gastric tumors, respectively. A significant correlation was found between VEGF and p53 status ( P <0.01).The expressions of VEGF were related to serosa invasion, lymph node metastasis and TNM stage ( P <0.01).There was a close relation between the expression of p53 and patient age, tumor location, vessel invasion, serosa invasion, lymph node metastasis and TNM stage ( P <0.05).The VEGF and P53 expressions correlated with poor prognosis.Conclusions:VEGF expression may be regulated by p53.Both of the two factors relate to the clinicopathological characteristics and prognostic value in gastric cancer.

关 键 词：胃癌 血管内皮生长因子 P53基因 临床病理学特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]