核因子-κB在人脑肿瘤中的表达及意义  

Significance of NF-κB expression in human cerebral tumors

作　　者：陈保东[1] 袁先厚[1] 江普查[1] 陈卫国[1] 文志华[1] 

机构地区：[1]武汉大学附属中南医院神经外科,湖北武汉430071

出　　处：《中国癌症杂志》2003年第1期24-26,共3页China Oncology

摘　　要：目的 :探讨核因子 κB(nuclearfactorkappaB ,NF κB)在人脑肿瘤组织中的表达及意义。方法 :应用免疫组织化学方法检测NF κBP65在 1 0 6例人脑肿瘤中的表达 ,其中星形细胞肿瘤 64例、髓母细胞瘤 2 2例、脑膜瘤 2 0例。 1 0例正常大脑组织作为对照。结果 :星形细胞肿瘤、髓母细胞瘤及脑膜瘤中NF κBP65蛋白阳性表达率分别为54 7% (35 64)、36 4% (8 2 2 )和 5 0 % (1 2 0 ) ;1 0例正常脑组织中NF κBP65无 1例阳性表达。NF κBP65蛋白的表达在星形细胞瘤与脑膜瘤、髓母细胞瘤与脑膜瘤之间差异显著 (P <0 0 5)。结论 :NF κB组成性活化与脑恶性肿瘤的发生相关 ,NFPurpose:To evaluate the significance of NF κB P65 protein expression in various human cerebral tumors. Methods:The expression of NF κB P65 protein in 106 cases of cerebral tumors was studied immunohistochemically. 106 cases included 64 cases of astrocytic tumors and 22 cases of medulloblastoma and 20 cases of meningioma. 10 cases of normal brain tissue were employed as a control group.Results:The positive rate of NF κB P65 protein of 64 astrocytic tumor specimens was 54.7%; the positive rate of NF κB P65 protein of 22 cases of medulloblastoma was 36.4% and 5.0% for 20 cases of meningioma. In contrast, none of the normal tissues exhibited NF κB P65 protein staining. Significant difference were observed between astrocytic tumor group and meningioma, as well as between medulloblastoma and meningioma ( P <0.05).Conclusions:Constitutive activation of NF κB P65 may lead to oncogenesis, NF κB P65 is a new oncogenic protein related to human cerebral tumors.

关 键 词：核因子-ΚB 星形细胞肿瘤 髓母细胞瘤 脑膜瘤 免疫组织化学 

分 类 号：R739.4[医药卫生—肿瘤]