化学性内脏神经去除术对胰腺癌痛患者淋巴细胞T亚群水平的影响  

Effects of chemical splanchic denervation in reversion of T-lymphocyte subtypes level in patients suffering intractable pain with pancreatic carcinoma

作　　者：汪涛[1] 田伏州[1] 蔡忠红[1] 陈琪[1] 

机构地区：[1]成都军区总医院全军普通外科中心,四川成都610083

出　　处：《中国癌症杂志》2003年第1期52-54,共3页China Oncology

摘　　要：目的 :探讨化学性内脏神经去除对胰腺癌痛患者淋巴细胞T亚群水平的影响。方法 :采用B超介导腹腔神经节无水乙醇注射对 32例胰腺癌患者实施化学性内脏神经去除治疗 ,以缓解剧烈癌性疼痛。分别在治疗前、治疗后 3、7、1 5、30天检测外周血CD+ 3 、CD+ 4 、CD+ 8和 β 内啡呔 (β EP)水平 ,38例健康体检者作为正常对照。 结果 :32例胰腺癌痛患者镇痛治疗前CD+3 、CD+4 、CD+8水平明显低于对照组 (P <0 .0 1 ) ;化学性内脏神经去除术治疗后 ,癌痛组患者CD+3 、CD+4 、CD+8水平和血浆 β EP含量明显上升 ,较治疗前有显著性差异 (第 7天 ,P <0 .0 5 ;P <0 0 1 ) ;血浆 β EP变化 (第 3天 ,P <0 .0 1 )早于T亚群 (第 7天 ,P <0 .0 5)。结论 :化学性内脏神经去除术能明显改善胰腺癌痛患者T亚群抑制状态 ,βPurpose:To study the effects on T lymphocyte subtypes with chemical splanchic denervation for patients with pancreatic carcinoma and intractable pain.Methods:32 cases with advanced pancreatic carcinoma accepted chemical splanchic denervation-pure alcohol injection around celiac ganglion guided by B US to relieve the severe pain. The fasting peripheral blood concentration of CD + 3 ,CD + 4 ,CD + 8 and β endorphin were determined before treatment ,3rd,7th,15th and 30th day after therapy. 38 healthy persons were taken as control group.Results:The percentage of CD + 3 ,CD + 4 ,CD 8+ cell were apparently decreased in patients with pancreatic carcinoma comparing with control group( P <0.01), and the level of CD + 3 ,CD + 4 ,CD 8+ cell and β EP obviously increased after chemical splanchic denervation with significant difference(7 th day , P <0.05; P <0.01). Moreover, the change of β EP (3rd day , P <0.01) was found earlier than T lymphocyte subtypes (7th day , P <0.05). Conclusions:Our results suggest that chemical splanchic denervation could markely improve the inhibition of T lymphocyte subtypes on patients suffering intractable pain with pancreatic carcinoma, and β EP might participate in the immune regulative course.

关 键 词：胰腺肿瘤 癌性疼痛 化学性内脏神经去除 淋巴细胞T亚群 Β-内啡肽 

分 类 号：R735.9[医药卫生—肿瘤]