晚期胃癌术前选择性动脉内介入治疗  

Preoperative regional chemotherapy in advanced gastric carcinoma

作　　者：徐幼龙[1] 周金良[2] 金雪熙[1] 张世统[1] 陈国祥[1] 杨大明[1] 万剑慧[1] 杨华[2] 

机构地区：[1]上海市长宁区中心医院肿瘤科,上海200336 [2]上海市长宁区中心医院病理科,上海200336

出　　处：《中国癌症杂志》2003年第1期57-58,66,共3页China Oncology

摘　　要：目的 :研究晚期胃癌手术前选择性动脉内介入治疗的效果。方法 :1 999年 8月～ 2 0 0 1年 1 1月住院手术治疗的进展期胃癌患者 98例 ,手术前进行选择性动脉内介入治疗 ,回顾分析 1 997年～ 1 998年间收治的 60例进展期胃癌未作介入而直接手术作为对照组。从手术切除率以及病理切片观察癌细胞变化方面进行比较。结果 :介入组切除率为 78% ,对照组 68%。手术后病理切片观察癌细胞坏死情况 ,介入组有效率为 67% ,而对照组仅 8例癌细胞有轻度局灶坏死。结论 :手术前介入化疗对于进展期胃癌的患者能提高切除率 ,能大量杀伤肿瘤细胞 ,初步疗效令人满意。Purpose:To study the efficacy of preoperative selective intra arterial chemotherapy in advanced gastric carcinoma. Methods:Between August 1999 and November 2001, a total of 98 hospitalized patients with advanced gastric carcinoma who underwent selective intra arterial regional chemotherapy prior to surgery were recruited in this study. 60 patients with advanced gastric carcinoma on whom surgery were performed did not receive any preoperative regional anti cancer drugs between 1997 and 1998 and served as controls. The surgical resection rate and histologic investigations were compared. Results:The resection rate was 78% in regional chemotherapy group and 68% in control group. Tumor cell necrosis was investigated by postoperative pathological study and revealed that the response rate in regional chemotherapy group was 67%. Only 8 cases in control group showed mild focal necrosis. Conclusions:Preoperative regional chemotherapy in patients with advanced gastric carcinoma may enhance resection rate and destroy large numbers of tumor cells vigorously. The preliminary results are satisfying.

关 键 词：进展期胃癌 手术前介入 癌细胞变性 

分 类 号：R735.2[医药卫生—肿瘤]