抑郁症、精神分裂症脑结构异常的MRI研究  

Structural brain abnormalities in patients with depression and schizophrenia:a MRI study

作　　者：彭昌孝[1] 唐勇[1] 崔青[1] 刘文[1] 

机构地区：[1]南京医科大学附属脑科医院精神三科,江苏省南京市210029

出　　处：《中国临床康复》2003年第3期478-479,共2页Chinese Journal of Clinical Rehabilitation

基　　金：江苏省自然科学基金(BS97040)

摘　　要：目的:探讨精神分裂症和抑郁症脑结构改变特点。方法:研究51例首发精神分裂症、32例抑郁症和23例健康志愿者。以PANSS和HAMD减分率评定疗效。MRI测量第三脑室横径在内的17条径线。结果:病例组第三脑室横径、双侧外侧裂宽度显著增宽,胼胝体厚度显著减少。脑结构异常与疗效之间缺乏普遍相关。结论:脑结构异常可能构成了疾病的神经生物学基础,它们与疗效的关系尚有待进一步研究。AIM:To explore the structural brain abnormalities in depression and schizophrenia.METHODS :Quantitative MRI methods were used to address the regional specificity of structural brain abnormalities in 51first-epi sode patients with CCMD-2-R schizophrenia(mean age,28.02years)and 32patients with depression(meanage,39.50years)relative to23healthy controlsubje cts(mean age,35.43years).Allpatients were assessedwithPAN SSandHAMDatbaseline and 2months after treatment.Treatm ent response was evaluated accordin g to the decrease of PANSS and HAMD scores.RESULTS:Relative to healthy control subjects,bothschizophrenic and depressive patients group hada thirdv entricular enlargement,smaller temporallobe(leftandright ),anddecreaseddepthofcorpus callosum.No general correlation wa s found among structural brain abnormalities and clinical efficacy.CONCLUSION:These findings support the view that schizophrenia and depression may in volve disturbance of neurodevelopm ental processes in some patients.However,the correlation between structura l brain abnormalities and clinical efficacy remains uncertain.

关 键 词：精神分裂症 放射性核素显像 抑郁症 磁共振成像 第三脑室 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]