青年人脑梗死患者抗心磷脂抗体检测及其临床意义  

Cerebral infarction detection of anticardiolipin antibodies in young patients

作　　者：余传庆[1] 王芳[1] 王强[1] 刘同兴[2] 

机构地区：[1]安徽省淮南市第一人民医院神经内科,232007 [2]安徽省淮南市第一人民医院临检中心,232007

出　　处：《蚌埠医学院学报》2003年第2期143-144,共2页Journal of Bengbu Medical College

摘　　要：目的 :探讨≤ 4 5岁青年人脑梗死与抗心磷脂抗体 (ACA)的关系。方法 :用金标免疫斑点法测定≤ 4 5岁青年人脑梗死组 6 6例、>4 5岁脑梗死组 138例和非缺血性脑血管病组 6 9例患者血中ACA的阳性率。结果 :≤ 4 5岁脑梗死组患者的ACA阳性率 36 .4 % ,高于 >4 5岁脑梗死 2 0 .3% (P <0 .0 5 ) ,而两组的ACA阳性率均明显高于非缺血性脑血管病组 5 .8% (P <0 .0 1) ,多灶性脑梗死ACA阳性率 4 0 .8%明显高于单灶脑梗死 17.3% (P <0 .0 0 5 ) ,复发性脑梗死ACA阳性率 5 6 .5 %明显高于首发脑梗死组 16 .5 % (P <0 .0 0 5 )。结论 :ACA与脑梗死的发病有一定关系 ,与青年人脑梗死关系更为密切 ,ACA阳性者临床表现多发、再发倾向。Objective:To explore the relationship between anticardiolipin antibodies(ACA) and cerebral infarction in young adults.Methods:The tested persons were divided into 3 groups.In the first group,there were 66 patients whose ages were less than 45,in the second group,there were 138 patients whose ages were more than 45,and in the control group there were 69 patients with no ischemic cerebral vascular diseases.All were examined for ACA by a golden marked immune spots assay.Results:The ACA positive rate in the first group(36.4%) was greater than that in the second group(20.3%)( P <0.05).The ACA positive rate in the two groups were greater than that in the control group(5.8%)( P <0.01).The ACA positive rate in patients with multiple infarction(40.8%) was greater than that with single infarction(17.3%)( P <0.005).The ACA positive rate in patients with recurrent cerebral infarction(56.5%) was greater than that with first cerebral infarction(16.5%)( P <0.005).Conclusions:ACA has some relation with occurrence of cerebral infarction.It is more intimate with the cerebral infarction of young adults.The patients with positive clinical features of ACA tend to multiply and recur.

关 键 词：脑梗死 青年人 住院患者 抗心磷脂抗体 

分 类 号：R743.33[医药卫生—神经病学与精神病学]