放射性标记氨基酸的肿瘤基础研究  

Radiolabeled amino acids were applied to basic aspects in oncology

作　　者：杨晓诚[1] 胡怀湘[2] 霍力[2] 

机构地区：[1]黄山市人民医院 [2]北京大学

出　　处：《国外医学（放射医学核医学分册）》2003年第1期25-27,共3页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

摘　　要：随着代谢显像的不断发展,放射性标记氨基酸引起临床更多关注。弄清氨基酸代谢基础和标记氨基酸在肿瘤中的作用更显必要。目前临床最常用的氨基酸显像剂如11C-蛋氨酸、11C-酪氨酸和123I-碘代甲基酪氨酸等,与18F-FDGPET相比很少受炎症影响,对脑部肿瘤显像准确性更好,对其他类型肿瘤也显示出更多的临床意义。As the applications of metabolic imaging are expanding,radiolabeled amino acids has gained increased clinical interest.It is necessary to understand the basic aspects of amino acid metabolism and radiolabeled;and finally describe in the tumors.Have been most used clinically,such as,11 C-methionine,11 C-tyrosine and 123 I-iodomethyltyrosine.And the theoretic and clinical back-ground of amino acid imaging is clear and is fit for clinical applications.Contrasting with the 18 F-FDG PET suggested that is less troubled by interfering uptake in inflammatory tissues.There is a more accuracy in the brain tumors specially.In the other tumor types has been shown sufficiently.

关 键 词：放射性标记氨基酸 ^11C-蛋氨酸 ^11C-酪氨酸 ^123I-碘代甲基酪氨酸 肿瘤显像 

分 类 号：R730.4[医药卫生—肿瘤]