预防性治疗食管癌淋巴结转移  

Preventive treatment for lymph node metastasis in esophageal cancer

作　　者：刘劲松[1] 桑玫[1] 单娟[1] 王建华[1] 

机构地区：[1]河南省肿瘤医院放疗科,郑州450008

出　　处：《肿瘤》2003年第2期156-157,166,共3页Tumor

摘　　要：目的　评价化疗及放疗预防食管癌淋巴结转移的疗效。方法 :70例食管癌患者随机分为化疗预防组 (A组 ) 35例 ,放射预防组 (B组 ) 35例。结果　治疗后 2年 ,总的淋巴结转移率A组 34.2 9% ,B组 48.5 7% ( χ2 =1.472 ,P =0 .2 2 5 )。锁骨上颈部、纵隔、贲门胃左动脉旁、腹腔淋巴结转移率A组分别为 8.5 7% ,11.43 % ,8.5 7% ,5 .71% ,B组分别为 5 .71% ,31.43% ,5 .71% ,5 .71% χ2 与P值分别为 :χ2 =0 .2 15 ,P =0 .6 43;χ2 =4.15 8,P =0 .0 41;χ2 =0 .2 15 ,P =0 .6 43 ;χ2 =0 ,P =1.0 0。A组 (CR +PR) 91.43% ,B组 71.43% ( χ2 =4.6 2 9,P =0 .0 31) ,两组生存率差异有显著意义 ( χ2 =4.6 2 9,P =0 .0 31)。结论　食管癌淋巴结转移预防性治疗 ,以化疗放疗合并预防优于单独放疗预防。Objective To evaluate the effect of preventive treatment for lymph node metastasis in esophageal cancer. Methods 70 patients with esophageal cancer were randomizd into two groups. 35 patients was in Chemo-radio-preventive group (Group A) and 35 patients was in radio-preventive group (Group B). Results In the second year after treatment the total rate of lymph node metasrasis was 34.29%(12 /35) in Group A, 48.57%(17 /35) in Group B ( χ 2 =1.472,P =0.225). The rate of lymph node metastasis for supraclavicular, mediastinum, cardiac gastric and upper abdomen around esophagus was 8.57%(3 /35), 11.43% (4 /35),8.57%(3 /35), 5.71% (2 /35) in Group A. was 5.71% (2 /35),31.43%(11 /35), 5.71% (2 /35), 5.71% (2 /35) in Group B ( χ 2 =0.215,P =0.643. χ 2 =4.158,P=0.041. χ 2 =0.215,P=0.643. χ 2 =0,P = 1.00 ). The rate of (CR+PR)was 91.43%(32 /35) in Group A, was 71.43%(25 /35) in Group B( χ 2 =4.629,P= 0.031)The difference of the survival rate between the two groups was statistically significant. Conclusion Chemoradio-prevention is better than radiotherapy prevention alone for lymph node metastasis in esophageal cancer.

关 键 词：食管癌 淋巴结转移 预防治疗 

分 类 号：R735.1[医药卫生—肿瘤]