甜茶素提取物对STZ致高血糖大鼠的降血糖作用研究  

EFFECT OF RUBUSOSIDE EXTRACTS ON HYPERGLYCEMIC RATS INDUCED BY STREPTOZOTOCIN

作　　者：田翠平[1] 瞿伟菁[1] 孙斌[1] 李明娟[1] 汪虹[1] 黄晓青[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《营养学报》2003年第1期29-33,共5页Acta Nutrimenta Sinica

基　　金：上海市科技发展基金资助项目 ( N o. 0 0 3912 0 74)

摘　　要：目的 :　研究甜茶素提取物对 STZ致高血糖大鼠的降血糖效果及其降糖机制。方法 :　腹腔注射 STZ制备糖尿病大鼠模型 ,取成型的大鼠随机分阳性对照组、甜茶素提取物组和降糖灵组。同时设一正常组。灌胃 3 w后 ,测血糖、果糖胺、胰岛素和 SOD等指标。结果 :　甜茶素提取物能极显著地降低 STZ致高血糖大鼠血糖 ,增强其抗氧化能力 ,同时能刺激胰岛素的分泌。结论Objective: To study the anti hyperglycemic effect of rubusoside on diabetic rats induced by streptozotocin (STZ)and its mechanism . Methods: The STZ induced diabetic rats were dived into three groups and were given (ig.) saline, rubusoside and Phenformin respectively once a day. After three weeks, the levels of serum glucose, fructosamine, insulin,SOD were assayed. Results: Rubusoside could reduce the level of serum glucose significantly, enhance the ability of anti oxidation and stimulate the secretion of insulin in STZ induced diabetic rats. Conclusion: The action of rubusoside on secretion of insulin can be explained for the anti hyperglycemic effect.

关 键 词：甜茶素 链脲佐菌素 高血糖大鼠 胰岛素 

分 类 号：R285.5[医药卫生—中药学]