大豆异黄酮对去卵巢大鼠血脂及骨生化指标的影响研究  

Study of the effects of isoflavone on serum lipid and bone biochemical markers in ovariectomized rats

作　　者：那晓琳[1] 陈文华[1] 宋丹凤[1] 迟晓星[1] 崔洪斌[1] 

机构地区：[1]哈尔滨医科大学公共卫生院,哈尔滨150001

出　　处：《卫生研究》2003年第2期123-125,共3页Journal of Hygiene Research

基　　金：国家自然科学基金 (No.30 2 4 0 0 73)

摘　　要：探讨大豆异黄酮对去卵巢大鼠血清中血脂指标、骨代谢生化指标及激素水平的影响。选择 4月龄的Wistar大鼠 ,根据体重随机分为 6组。除 1组行单纯开腹手术外 ,其它 5组均切除双侧卵巢 ,分别为 :去卵巢对照组 ;高剂量大豆异黄酮组 ;中剂量大豆异黄酮组和低剂量大豆异黄酮组 ;雌激素组。喂养 16周后 ,处死大鼠 ,分离血清进行分析指标的测定。结果发现 :给予去卵巢大鼠大豆异黄酮后 ,血清中高密度脂蛋白(HDL)含量与去卵巢对照组相比有所增高 (P <0 0 5 ) ;总胆固醇 (TC)、甘油三酯 (TG)指标下降 ;骨吸收指标显著降低 ,骨形成指标骨钙素水平与去卵巢组比有所提高 ;同时 ,大鼠切除卵巢后 ,体内雌激素水平显著下降。结果显示 :大豆异黄酮对去卵巢大鼠的血脂有一定的调节作用 。The effects of isoflavone on serum lipid and bone biochemical markers in ovariectomized rats were studied. Four month old Wistar rats were divided into 6 groups according to their weights. Rats were either sham operated or ovariectomized (ovx). Some ovx rats were given different dosage of isoflavone or estrostilben. Sixteen weeks later, the rats were killed and the serum were separated to determine the analytical indexs. The experiment results show that in the group of isoflavone the content of serum HDL and bone formation index bone γ carkoxyglutamate protein (BGP) increase ,but total cholesterol (TC),triglycerides (TG) and bone absorption index tartrate resistant acid phosphatase (TRAP )decrease obviously. The results from this study indicate that isoflavone can modulate serum lipid and inhibit bone absorption.

关 键 词：去卵巢大鼠 大豆异黄酮 血脂 骨生化指标 

分 类 号：R711.75[医药卫生—妇产科学]