射频透热联合动脉持续灌注化疗治疗晚期肠癌的临床疗效  

Radiofrequency hyperthermia in combination with continuous intra-arterial infusion chemotherapy in the treatment of advanced colorectal cancer

作　　者：赵燕[1] 汪森明[1] 张健[1] 周稳 

机构地区：[1]第一军医大学珠江医院肿瘤科,广州510282

出　　处：《中华物理医学与康复杂志》2003年第2期80-82,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的　观察射频热疗联合介入持续动脉化疗治疗 2 1例晚期大肠癌患者的临床初步疗效。方法　对 2 1例局部复发和伴有肝、肺、骨、腹腔、盆腔及腹股沟淋巴结转移的晚期大肠癌患者经射频热疗联合供养靶动脉介入灌注化疗。每名患者至少进行 2个周期的介入化疗联合热疗。化疗方案为第 1～ 3天CF2 0 0mg/m2 ,静脉滴注 ;第 1天DDP 80mg/m2 ,第 1～ 3天如肾功能改变则改用Vp 1 6 60mg/m2 ,动脉滴注 ;5 FU2 50 0mg/m2 ,持续动脉滴注 72h。肝转移血供丰富者 ,先将ADM 30mg/m2 和MMC 6mg/m2 加入超液化碘油1 0～ 30ml中进行肝动脉灌注栓塞。热疗频率 40 .68MHz,电容式加热 ,电极直径 2 0～ 2 5cm ,入射功率 50 0～ 80 0W ,反射功率 2 0～ 40W。插管化疗第 2天开始进行热疗 ,每 72h 1次 ,每次 50～ 70min ,每疗程化疗配合 4～ 8次热疗。结果　病灶近期疗效以CT或B超检查结果作为评价标准 ,CR 0例 ,PR 1 4例 ,总有效率为 66 .67%。患者化疗未出现严重的不良反应。热疗不良反应为局部疼痛和脂肪硬结 ,不需特殊处理。结论射频热疗联合介入持续动脉化疗是治疗晚期大肠癌的安全、有效的治疗方法 。Objective To observe the therapeutic efficacy of continuous arterial infusion chemotherapy combined with radiofrequency hyperthermia in the treatment of patients with advanced colorectal cancer. Methods A total of 21 advanced colorectal cancer patients with various distant metastasis were treated by the combined continuous intra arterial infusion chemotherapy and radiofrequency hyperthermia. For the chemotherapy, a dose of 200mg/m 2 surface body area of calcium folinate (CF) was given for 1 to 3 days. 80mg/m 2 of cisplation was infused intravenously for the first day and replaced by etoposide Vp 16, 60mg/m 2 for 1～3days in patients with renal dysfunction. For intra arterial infusion, a dose of 500mg/m 2 5 FU 2 was given for 72 hours. For patients with liver metastases, chemoembolization(ADM 30mg/m 2+MMC 6mg/m 2 mixed with ultra liquefied lipiodol) was carried out. Radiofrequency hyperthermia with a frequency of 41MHz was performed on the second day after chemotherapy. Results Response rates were assessed by CT scan and ultrasonography. The overall response rate of the cases was 66.67%. No serious side effect or complication was found in the course of chemotherapy. Local pain and lipid nodule were occasionally observed in some patients after hyperthermia. Conclusion Continuous intra arterial infusion chemotherapy in combination with radiofrequency hyperthermia is an useful and safe method for the treatment of patients with advanced colorectal cancer.

关 键 词：疗效 晚期大肠癌 射频热疗 化疗 

分 类 号：R735.3[医药卫生—肿瘤]