急性脑梗塞患者血清白细胞介素-6和肿瘤坏死因子-α的测定及临床意义  

Clinical signifieance of serum interleukin-6 and tumor necrosis factor-αinpatients with acute cerebral infarction

作　　者：崔景彬[1] 胡军[2] 郭林 王俊萍[1] 

机构地区：[1]郑州大学基础医学院生物化学教研室,河南郑州450052 [2]郑州大学基础医学院微生物学与免疫学教研室,河南郑州450052 [3]河南省电力医院,河南郑州450052

出　　处：《河南医学研究》2003年第1期41-42,共2页Henan Medical Research

摘　　要：目的 :探讨急性脑梗塞患者血清中白细胞介素 6((IL 6)及肿瘤坏死因子 α(TNF α)在发病中的作用及临床意义。方法 :采用酶联免疫法测定 45例急性脑梗塞患者血清IL 6和TNF α含量 ,并与 3 6例正常对照组比较。结果 :急性脑梗塞患者血清IL 6和TNF α水平均显著高于正常组 ,恢复期两种细胞因子有下降的趋势 ,但仍高于正常。结论 :脑梗塞发病过程中存在IL 6和TNF α介导的炎症和免疫反应 ,IL 6和TNFObjective: To investigate the role of interleukin 6(IL 6) and tumor necrosis factor α(TNF α) in patients with acute cerebral infarction ,and their clinical significance.Methods: The concentration of serum IL 6 and TNF α were measured with enzyme linked immunosorbend assay in 45 patients with acute cerebral infarction, and the results were compared with those in 36 healthy control. Results: The serum IL 6 and TNF α levels in patients were significantly higher in acute and convalescent patients with cerebral infarction than that of control group. Then the levels of these cytokins decreased in convalescent patients with cerebral infarction, but they were still higher than normal. Conclusion: There are some inflammatory and immunological response mediated by IL 6 and TNF α in the pathogenesis of cerebral infarction. The determination of serum IL 6 and TNF α levels could be prognostic to the development and treatment of cerebral infarction.

关 键 词：急性脑梗塞 血清 白细胞介素-6 肿瘤坏死因子-Α 测定 临床意义 

分 类 号：R743.33[医药卫生—神经病学与精神病学]