视神经再生模型的超微结构  

Ultrastructural Observation of Optic Nerve Regeneration Model

作　　者：朱益华[1] 朱捷[1] 唐宝丰[1] 徐国兴[1] 王玮[2] 周琳瑛[3] 韩晓丽[1] 林发森[1] 

机构地区：[1]福建医科大学附属第一医院眼科,福州350005 [2]福建医科大学神经生物学研究中心,福州350004 [3]福建医科大学电子显微镜室,福州350004

出　　处：《福建医科大学学报》2003年第1期35-37,共3页Journal of Fujian Medical University

基　　金：福建省自然科学基金资助项目 ( 2 0 0 0 F0 0 4)

摘　　要：目的　观察正常大鼠视神经及坐骨神经的超微结构 ,了解视神经 -坐骨神经吻合模型吻合段超微结构在不同时间的变化。　方法　建立视神经 -坐骨神经吻合模型 ,第 15 ,30 ,4 5及 6 0天取出吻合段神经组织 ,透射电镜观察。　结果　正常大鼠坐骨神经纤维较视神经纤维明显增粗 ,吻合 15 d,神经细胞明显变性、水肿及坏死 ,吻合30 ,4 5及 6 0 d,有髓神经纤维的结构逐渐恢复。Objective\ To investigate the microstructural changes of anastomosed segment of optic nerve with sciatic nerve.\ Methods\ Models of autologuous sciatic nerve segment transplanted into the optic nerve of rats were performed and anastomosed nerve tissue were removed and examined by electron microscopy after experimental days.\ Results\ Optic nerve fiber was smaller than sciatic nerve fiber.\ Never cells were degeneration\|edema and necrosis in 15th day.\ Pithy nerve fiber recovered gradually in 30, 45, 60th day after transplatation.\ Conclution\ Sciatic nerve transplatation can support the regeneration of optic nerve probably. \;

关 键 词：视神经 坐骨神经 神经再生 

分 类 号：R-332[医药卫生]