双相情感障碍与DRD3、DRD2和COMT基因多态性的关联分析  

Association study of dopamine D3, D2 receptor gene and COMT gene polymorphism with bipolar affective disorder

作　　者：马小红[1] 周琴[2] 李涛[1] 王英成[1] 黄颐[1] 孙学礼[1] 刘协和[1] 师建国[3] 吴斌[3] 

机构地区：[1]四川大学华西医院心理卫生研究所,成都610041 [2]复旦大学公共卫生学院卫生统计与社会医学教研室 [3]西安市精神卫生中心

出　　处：《中国神经精神疾病杂志》2003年第2期84-87,共4页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的　探索多巴胺D3受体 (DRD3)、多巴胺D2受体 (DRD2 )和儿茶酚氧位甲基转移酶 (COMT)基因多态性与双相情感障碍的关系。方法　使用病例 对照的关联分析方法 ,对 10 5名双相情感障碍患者和 12 8名对照者之DRD3、DRD2和COMT的多态性进行检测 ,并进行关联分析。结果　DRD3等位基因在两组间的分布有显著性差异 (χ2 =5 77,P =0 0 2 ) ,Logistic多元回归分析发现基因型 1/ 1和 2 / 2在两组间分布的有显著性差异 (P =0 0 36 ,OR=5 72 7) ,等位基因分析也有显著性差异 (P =0 0 2 2 ,OR =6 786 ) ;DRD2和COMT基因型和等位基因的分布在两组间无显著性差异 (χ2 =1 983,P =0 37/ χ2 =1 6 7,P =0 4 1;χ2 =0 2 16 ,P >0 0 5 / χ2 =0 14 3,P >0 0 5 ) ;将DRD3和DRD2共同分析时发现OR值升高 (OR =6 6 97)。结论　DRD3基因多态性与双相情感障碍有关联 ,且与DRD2有协同作用。Objective To explore the relationship between dopamine D3 (DRD3), dopamine D2 (DRD2), catechol O methyltransferase (COMT) genes polymorphism and bipolar affective disorder. Methods The case control association study was used to analyze the association of polymorphism in the DRD3, DRD2, COMT genes with 105 patients of bipolar affective disorder and 128 controls. Results There was significant difference in allelic distribution of DRD3 polymorphism between patients and controls ( χ 2=5 77, P =0 02); significant different in the distribution of the genotype 1/1 and 2/2 of DRD3 in these two groups was found by using Logistic regression analysis ( P =0 036, OR =5 727), and there was significant difference in allelic too ( P =0 022, OR =6 786); there was no significant difference in genotypic/allelic distribution of DRD2 and COMT polymorphism between the two groups ( χ 2=1 983, P =0 37/ χ 2=1 67, P= 0 41; χ 2=0 216, P >0 05/ χ 2=0 143, P >0 05); OR value was higher in analyzing DRD3 and DRD2 together than separately ( OR =6 697)?Conclusions Polymorphism of DRD3 gene is significantly associated with bipolar affective disorder and cooperate with DRD2.

关 键 词：双相情感障碍 多巴胺D3受体 多巴胺D2受体 儿茶酚氧位甲基转移酶 

分 类 号：R749.4[医药卫生—神经病学与精神病学]