急性脑梗死患者止凝血相关因子变化的研究  

Investigation of changes of hemostatic and coagulative factors in acute cerebral infarction

作　　者：董幼镕[1] 翟宇[1] 陆勤[1] 

机构地区：[1]上海第二医科大学附属第九人民医院神经内科,上海200011

出　　处：《上海医学检验杂志》2003年第2期94-96,共3页Shanghai Journal of Medical Laboratory Sciences

摘　　要：目的　探讨脑梗死患者止凝血系统的改变及其临床意义。方法　检测 5 2例脑梗死患者和 5 5例正常人的外周血血管性血友病因子 (vWF)、因子Ⅷ活性 (FⅧ∶C)、血栓调节蛋白 (TM )、蛋白C(PC)、游离蛋白S(FPS)、组织纤溶酶原激活物 (t PA)、组织纤溶酶原激活剂抑制剂 (PAI 1)、β TG、PF4 的含量和血小板粘附试验(PAdT)及血小板聚集试验 (PAgT) ,并进行统计学分析。 结果　脑梗死组vWF、FⅧ :C、PC、PAI 1、β TG、PF4 、PAdT及PAgT较对照组增高 ,t PA下降 ,患者组TM及FPS含量与对照组无明显差异。 结论　提示脑梗死患者凝血活性增强、纤溶活性减低 。Objective To investigate the changes of hemostatic and coagulative systems and their clinical significances in acute cerebral infarction (ACI). Methods Levels of vWF,FⅧ:C,TM,PC,FPS,t-PA,PAI-1:A,β-TG,PF 4, PAdT and PAgT in peripheral blood were detected and statistically analyzed in 52 ACI patients and 55 control subjects. Results Compared with control subjects, the levels of vWF, FⅧ:C,PC,PAI-1,β-TG,PF 4,PAdT and PAgT in ACI patients were higher, while the level of t-PA was lower. TM and FPS levels showed no differences between patients and control groups. Conclusions There are increasement of blood clotting activity, decreasement of fibrinolysis activity and hyperfunction of platelet in the patients with cerebral infarction.

关 键 词：急性脑梗死 相关因子 止血 凝血 

分 类 号：R743.33[医药卫生—神经病学与精神病学]