鼻咽癌中p21/WAF1和VEGF的表达研究  

The Expression of p21/WAF1 and VEGF in the Nasopharyngeal Cancer

作　　者：朱冲林[1] 刘勇[1] 

机构地区：[1]江西省人民医院,南昌330006

出　　处：《中国眼耳鼻喉科杂志》2003年第2期96-97,共2页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：目的探讨鼻咽癌中p21/WAF1和VEGR表达异常的意义。方法免疫组织化学(SP)方法和显微摄像计算机图象分析技术。结果 55例鼻咽癌中p21/WAF1阳性32例(58.2%);VEGF阳性27例(49.1%);30例慢性炎症标本p21/WAF1阳性25例(83.3%),VEGF阳性4例(13.3%),鼻咽癌与慢性炎症中p21/WAF1和VEGF的表达差异具有显著性(P<0.01)。淋巴结转移阳性组的p21/WAF1阳性率(44.4%)显著低于阴性组(84.2%),P<0.05。淋巴结转移阳性组的VEGF阳性率(69.4%)显著高于阴性组(10.5%),P<0.05。结论提示p21/WAF1的低表达和VEGF的过表达在鼻咽癌细胞增殖和转移过程中起重要作用。Purpose To study the value of expression p21/WAF1 and VEGF in the nasopharyngeal cancer. Methods S-P immunohistochemical methods and the picture analyzing system in computer were used. Results The expression of p21/WAF1 was 32 postive (58.2%) and the expression of VEGF was 27 postive (49.1%) in the nasopharyngeal cancer. There was a statistially significant difference between the expression of p21/WAF1 and VEGF in the nasopharyngeal cancer and chronic inflammation. The expression of p21/WAF1 in the nasopharyngeal cancer with lymphnode metastasis (44.4%) was significantly lower than that in the nasopharyngeal cancer without lymphnode metastasis (84. 2%), P < 0.05.The expression of VEGF in the nasopharyngeal cancer with lymphnode metastasis(69.4%)was significantly higher than that in the nasopharyngeal cancer without lymphnode metastasis(10.5%), P <0.05.Conclusion The results show that p21/WAF1 low expression and VEGF high expression play an important role in cell proliferation and matastasia of nasopharyngeal cancer.

关 键 词：鼻咽癌 基因 血管内皮生长因子 免疫组织化学 

分 类 号：R739.63[医药卫生—肿瘤]