宫颈癌腔内微波热疗加放疗综合治疗疗效观察  

Radiotherapy combined with hyperthermia for uterine cervix carcinomaZ

作　　者：李莎[1] 殷莉萍[1] 赵瑞[1] 

机构地区：[1]兰州军区总医院放疗科,730050

出　　处：《兰州医学院学报》2003年第1期55-56,共2页Journal of Lanzhou Medical College

摘　　要：目的　观察腔内微波热疗十放射治疗宫颈癌的临床疗效。方法　 1 996年 2月至 1 998年 2月我院收治的 6 1例宫颈癌患者随机分为两组 :热疗十放疗组 (H +R组 ) 3 0例 ,单纯放疗组 (R组 ) 3 1例。两组均采用 8MV -X线治疗 ,全盆剂量 3 8～ 40Gy,宫旁剂量 1 0～ 1 8Gy。1 92 Ir-HDR腔内放疗剂量 3 0～ 3 6Gy。H +R组采用 91 5MHz微波热疗仪 ,阴道内辐射器加温 42～ 45℃ ,45分钟 /次 ,2～ 3次 /周 ,共 4～ 6次 ,放疗前、后半小时进行。结果　局部肿瘤缩小率H +R组CR1 0 0 % ,R组CR77.4%。两组差异显著 (P <0 .0 1 )。生存率 :l、2年生存率两组无统计学意义 ,3年生存率H +R组优于R组 ,有显著差异 (P <0 .0 5 )。结论　热疗十放疗能增加宫颈、阴道上 1 /3恶性肿瘤的敏感性 ,提高宫颈癌患者的局部控制率和生存率 。Objective To evaluate the therapeutic result of carcinoma of uterine cervix treated by radiotherapy combined with hyperthermia.Methods 61 patients were treated from Febrary 1996 to Febrary 1998. They were randomized into two groups:30 patients treated by radiotherapy plus hyperthermia (H+R), 31 patients treated by radiotherapy alone (R). A midplane dose of 38-40 Gy to the whole pelvis and 10-18 Gy to the parametrical areas were given using 8 MV X rays, combined 30-36 Gy with 192 Ir HDR intracavitary brachytherapy. Hyperthermia was given half an hour before or after radiotherapy. The temperature was increased and maintained at 42-45℃ for 45 minutes with 915MHz microwaves. Hyperthermia was totally given 4-6 times in two weeks.Results The local control rates of H+R and R groups were 100% and 77.4% ( P <0.01). The 3-year survival rates of H+R group was better than R alone group ( P <0.05), although the 1- and 2-year survival rates showed no statistical significance. Conclusion Increasing the radiosensitivity of cervix and 1/3 upper vagin, hyperthermia combined with radiotherapy is able to enhance the local control rate and survival rate for the patients with carcinoma of uterine cervix.

关 键 词：宫颈癌 腔内微波热疗 放射疗法 综合治疗 疗效观察 

分 类 号：R737.33[医药卫生—肿瘤] R730.5[医药卫生—临床医学]