儿童横纹肌肉瘤中p16蛋白的表达及其意义  

The Significance of p16Protein Expression in Children Rhabdomyosarcoma

作　　者：胡晓丽[1] 王学文[1] 宋兰云[1] 宁培儒[1] 

机构地区：[1]天津儿童医院病理科,300074

出　　处：《天津医药》2003年第4期198-200,共3页Tianjin Medical Journal

摘　　要：目的 :探讨横纹肌肉瘤 (RMS)中 p16蛋白表达及其与RMS的发生、浸润和转移的关系。方法 :应用免疫组化方法检测30例RMS病人中 p16蛋白的表达情况。结果 :30例RMS中 p16蛋白表达异常为26例 ,正常表达4例 ,与正常组比较 ,有非常显著性差异 (P=0.0001)。在21例 p16蛋白阳性的病例中 ,有5例发生转移 ,而在p16蛋白阴性的9例中有7例发生转移 ,两组之间有显著性差异 (P=0 0125)。p16蛋白在胚胎性RMS(ERMS)和腺泡状RMS(ARMS)中的表达无显著性差异 (P=1.0000)。结论 :(1) p16蛋白的异常表达与RMS的发生密切相关。(2) p16蛋白的表达缺失与RMS的广泛浸润和转移有关。(3) p16蛋白在不同类型RMS中的表达无明显差异。Objective:To investigate p16protein expression in children rhabdomyosarcoma(RMS)and the relationship of the expression and etiology,invasion,or metastasis.Methods:Thirty cases of RMS were studied for p16protein expression with immunohistochemical method.Results:The abnormal expression of p16protein occurred in26cases,and the normal expression of p16in4cases.The abnormal expression in RMS group was significantly higher than that in control group(P=0.0001).Metastasis occurred in5cases of21patients who had positive expression of p16,5,and in7cases of9patients with negative expression of p16,7(P=0.0125).Conclusion:(1)The abnormality of p16is highly related to the pathogenesis of RMS.(2)Loss of p16has relation to invasion or metastasis.(3)The abnormal expression of p16is not related to pathological type.

关 键 词：横纹肌肉瘤 免疫组织化学 儿童 P16 基因表达 临床意义 

分 类 号：R738.7[医药卫生—肿瘤]