膜引导组织再生术与自体静脉桥接法修复面神经缺损的实验研究  

Experimental Study on Using mGTR and Venous Autografts to Repair Facial Nerve Defects in Rabbits

作　　者：马跃[1] 徐欣[1] 辛宁宁[1] 王继同[1] 黄海云[1] 

机构地区：[1]山东大学口腔医学院,山东济南250012

出　　处：《上海口腔医学》2003年第1期38-40,共3页Shanghai Journal of Stomatology

基　　金：山东省自然基金(Q99c14)

摘　　要：目的观察并比较膜引导组织再生术和静脉桥接法修复面神经的作用和效果。方法分别采用膜引导组织再生术和自体静脉桥接法对家兔进行面神经缺损修复,以自体神经移植为对照,通过电生理学和组织学方法,观察和比较两种修复方法的效果。结果两种方法都具有修复面神经缺损的作用,但效果存在一定差别。膜引导组织再生组,术后3个月时两侧面神经干传导速度之差值为(2.10±1.2)m/s,而静脉桥接组为(6.80±1.4)m/s,神经移植组为(2.16±1.6)m/s。组织学上,膜引导组织再生组,术后3个月神经纤维排列整齐,延续连贯;静脉桥接组,神经纤维排列不整齐,结缔组织增生明显。结论膜引导组织再生术和自体静脉桥接法均可用于面神经缺损的修复,膜引导组织再生术的修复效果优于自体静脉桥接法。Objective To observe and compare the effects of using mGTR and venous autografts to repair the defect of facial nerve in rabbits.Methods mGTR and venous autografts were performed on three groups of rabbits.Then physical and histological examinations were carried out to get the results of these two repair methods.Results Both the two methods can induce regeneration of facial nerve.The mGTR is more effective and faster in repairing the nerve defect.Three months after operation,the distance of NCV between bilateral facial nerve in mGTR group was(2.10±1.2)m/s,(6.80±1.4)m/s in venous autografts,(2.16±1.6)m/s in nerve transplantation group.Histologically,the facial nerve fibers were arranged regularly and in continuity in mGTR,the facial nerve fibers were arranged irregularly with marked hyperplasia of connective tissues in venous autografts three months after repair.Conclusions The mGTR is more effective than venous autografts in repair of facial nerve.

关 键 词：面神经缺损 膜引导组织再生术 静脉桥接法 组织学 电生理学 

分 类 号：R782[医药卫生—口腔医学]