Synthesis of 2-and 5-(1,1-Dimethyl-1,2,5,6-tetrahydropyridinium-3-yl)oxadiazoline Iodides  

作　　者：胡国强 黄文龙 张惠斌 黄胜堂 汪海 

机构地区：[1]CenterofDrugDiscovery,ChinaPharmaceuticalUniversity,Nanjing,Jiangsu210009,China [2]InstituteofPharmacologyandToxicologyAcademyofMilitarySciences,Beijing100850,china

出　　处：《Chinese Journal of Chemistry》2002年第10期1115-1120,共6页中国化学（英文版）

基　　金：ProjectsupportedbytheMajorStateBasicResearchDevelopmentProgramofChina (No.19980 5 1112 )

摘　　要：A series of 2- and 5-(1,1-dimethyl-1,2,5,6-tetrahydropyridinium-3-yl)oxadiazoline iodides, which might be used as M 1 muscarinic receptor agonists, was synthesized from nicotin-aldehyde and nicotinhydrazine, respectively. Their structures were characterized by 1H NMR, IR, MS spectra and elemental analysis.A series of 2- and 5-(1,1-dimethyl-1,2,5,6-tetrahydropyridinium-3-yl)oxadiazoline iodides, which might be used as M 1 muscarinic receptor agonists, was synthesized from nicotin-aldehyde and nicotinhydrazine, respectively. Their structures were characterized by 1H NMR, IR, MS spectra and elemental analysis.

关 键 词：TETRAHYDROPYRIDINE oxadiazoline muscarinic receptor agonist synthesis 

分 类 号：O626[理学—有机化学]