大剂量维生素C治疗病毒性心肌炎的机制  

Effective mechanisms of high-dosage vitamin C on viral myocarditis

作　　者：陈建斌[1] 饶邦复[1] 常静[1] 

机构地区：[1]重庆医科大学附属第一医院内4科,重庆400016

出　　处：《华西药学杂志》2003年第1期22-25,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的　探讨大剂量维生素C治疗病毒性心肌炎 (VMC)的相关机制。方法　雄性Balb/c小鼠随机分为柯萨奇B3 病毒(coxsackieB3 ,CVB3 )感染组、CVB3 感染加大剂量维生素C治疗组和对照组。采用酶组织化学法分析心肌线粒体琥珀酸脱氢酶(SDH)和细胞色素氧化酶 (CCO)活性 ;反相高效液相色谱法测定心肌腺苷酸含量。结果　VMC小鼠心肌超氧化物歧化酶(SOD)活性降低、丙二醛 (MDA)含量升高 ;线粒体SDH、CCO活性降低 ;心肌腺苷酸含量下降。不同时相点治疗组相应指标均较感染组显著改善。结论　VMC心功能减退与心肌腺苷酸含量下降有关 ;大剂量维生素C通过抗脂质过氧化 ,能有效保证心肌线粒体功能 ,改善能量代谢 。OBJECTIVE To explore the effective mechanisms of high-dosage vitamin C on viral mycarditis.METHODS The male Balb/c mice were randomly divided into three groups:CVB 3 infection,CVB 3 infection group with high dosage vitamine C treatment group and control group.The activities of SDH and CCO of myocardial mitochondria were studied by enzyme histochemical methods.The RP-HPLC was used to analyze the contents of myocardial ATP,ADP and AMP.RESULTS Comparing with control group,the myocardial SOD activity decreased and the content of MDA increased,while the activities of SDH and CCO of mitochondria declined obviously and the contents of ATP,ADP as well as AMP declined notably in the infection group.CONCLUSION The cardiac dysfunction is related to energy production in myocardium of viral myocarditis.High-dosage vitamin C can inhibit liqid peroxidation,protects myocardial mitochondrial function,ameliorats myoardial energy metabolism and improves prognosis.

关 键 词：病毒性心肌炎 VMC 维生素C 治疗 治疗机制 线粒体琥珀酸脱氢酶 细胞色素氧化酶 腺苷酸 超氧化物歧化酶 

分 类 号：R542.21[医药卫生—心血管疾病] R977.23[医药卫生—内科学]