克罗恩病患者促炎性细胞因子肿瘤坏死因子-α和白细胞介素-6促炎作用的研究  

Proinflammatory Cytokines: Tumor Necrosis Factor-a and Interleukin-6 in Patients with Crohn's Disease

作　　者：戴向东[1] 牛凤丽[2] 郑萍[2] 

机构地区：[1]昆山市第二人民医院消化内科,215300 [2]上海第二医科大学附属仁济医院消化内科

出　　处：《胃肠病学》2003年第1期33-34,共2页Chinese Journal of Gastroenterology

摘　　要：背景:近年来许多研究证明肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6在炎症的发生中起重要作用。目的:研究克罗恩病(CD)患者血清TNF-α和IL-6水平的变化,探讨它们在CD发病中的作用。方法:以健康成人作为对照,用酶联免疫吸附测定(ELISA)方法测定CD活动期和缓解期患者的血清TNF-α和IL-6水平,同时测定血沉(ESR)、血小板计数和C反应蛋白(CRP)。结果:活动期CD患者的血清TNF-α和IL-6水平均显著高于缓解期患者和健康成人(TNF-α;P<0.05,IL-6:P<0.01),与ESR、血小板计数和CRP的变化一致。结论:TNF-α和IL-6在CD患者的炎症发生中起重要作用,可作为CD活动期的新标志物。Background: Tumor necrosis factor (TNF)-ot and interleukin (IL)-6 have been demonstrated to play proinflammatory role. Aims: To study the serum levels of TNF-a and IL-6 in patients with Crohn's disease, and their functions in the pathogenesis of Crohn's disease. Methods: The serum levels of TNF-a and IL-6 in patients with active or remission stage of Crohn's disease and healthy adult controls were assayed by enzyme-linked immunosorbent assay (ELISA). Meanwhile, erythrocyte sedimentation rate (ESR), platelet count and C reactive protein (CRP) were tested. Results: The serum levels of TNF-a and IL-6 in patients with active stage of Crohn's disease were significantly higher than those with remission stage and healthy adult controls (TNF-a: P<0.05, IL-6: P<0.01), and they were consistent with ESR, platelet count and CRP. Conclusions: TNF-a and IL-6 play proinflammatory role in the pathogenesis of Crohn's disease and may serve as new markers of active stage for Crohn's disease.

关 键 词：克罗恩病 促炎性细胞因子 肿瘤环死因子-α 白细胞介素-6 IL CD CROHN病 

分 类 号：R574.62[医药卫生—消化系统]