臂丛神经根性撕脱伤动物模型的实验研究  

Experimental study on animal model of brachial plexus root avulsion injury

作　　者：朱清远[1] 王玉发[1] 王国君[1] 许则民[1] 齐宏彬[2] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130021 [2]吉林大学第一医院,吉林长春130021

出　　处：《吉林医学》2003年第2期133-135,共3页Jilin Medical Journal

摘　　要：目的:为臂丛神经实验外科提供更加科学准确的动物模型。方法:60只SD大鼠,随即分为3组。A组:切断肌皮神经主干。B组:切断颈6及加入其中的颈7分支后将其近端撕脱。C组:切断颈5、6、7后将其近残端尽量拉出剪断。左侧为实验侧,右侧为正常侧,进行自身对照。术后定期检测电生理学、组织学及肌肉功能等指标。结果:A组和C组术后实验侧与正常对照侧相比各项指标均有显著性差异;B组术后早期肱二头肌虽有轻微改变,但晚期实验侧与正常对照侧相比各项指标无显著性差异。结论:切断大鼠肌皮神经主干,或者切断颈6的同时将颈5和颈7切断,然后近端撕脱,可以准确模拟臂丛神经根性撕脱伤。Objective To provide a more scientific and precise animal model for experimental surgery of brachial plexus.Method60SD rats were randomly divided into3groups.In group A,the musculocutaneous nerves were cut off.In group B,C6and branches from C7were cut off.In group C,C5,C6and C7were cut off.In all groups,their proximal ends were avulsed.(The left sides were experimental sides and)the right sides were self-comparison.The indicators of electrophysiology,tis-sue and muscular function were appraised regularly in each group.Results In group A and group C,there were obvious differ-ence in every indicator between experimental sides and normal sides.In group B,although there were a little change of biceps brachial muscle in early stage after operation,there was no significant difference between experimental sides and normal sides as in the late stage.Conclusion Cutting off musculocutaneous nerve,or cutting off C6,C5and C7at the same time ,then mak-ing their proximal ends avulsed can make an animal model accurately mimic brachial plexus root avulsion injury in rat.

关 键 词：臂丛神经根性撕脱伤 动物模型 手术方法 观察指标 肌电图 

分 类 号：R-332[医药卫生]