乙型肝炎肝硬化患者白细胞Apo2.7的表达及临床意义  

Clinical significance of Apo2.7 antigen expression in cirrhotic patients

作　　者：陈公英 李敏伟 娄国强[2] 

机构地区：[1]浙医一院传染病研究所,310003 [2]杭州市第六人民医院,310000

出　　处：《浙江临床医学》2003年第4期242-243,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 白细胞减少在肝硬化患者中极为常见 ,而白细胞减少往往预示易于发生细菌感染 ,加剧肝病发展。作者从外周血检查是否存在细胞凋亡过强 ,以探索白细胞减少的机制。方法 30例肝硬化白细胞计数≤2×109/L患者为研究对象(A组) ,25例肝硬化白细胞相对不低者(B组)及20例健康献血员为对照组(C组)。用流式细胞术Apo2.7法 ,检测淋巴细胞、粒细胞Apo2.7的表达 ,了解细胞凋亡状况。结果 肝硬化白细胞显著减少患者Apo2.7值显著升高 ,与对照组比较有显著差异(p<0.05)。结论Objective Cirrhosis patients frequently menifest leukomia are predisposed to bacterial infections. we examined leukocyte apoptosis to determine the mechanism of leukomia. Method Achrocyte and granulocyte of 55 cirrhosis patients(A?B group)and 20 healthy volunteers (C group)were analyzed for Apo2.7 antigen expression by flow cytometry. Result the level of achrocyte and granulocyte of Apo2.7 antigen expression in cirrhosis patients were significantly higher. Conciusion Achrocyte and granulocyte from cirrhotic patients exhibited markedly accelerated apoptosis via which mechanism of leukomia in cirrhosis patients may be in part explained.

关 键 词：乙型肝炎肝硬化 白细胞 APO2.7 细胞凋亡 临床意义 

分 类 号：R575.2[医药卫生—消化系统]