扎托洛芬的合成  

Synthesis of Zaltoprofen

作　　者：金辉[1] 杨宇[1] 唐维高[1] 钟裕国[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2003年第2期118-119,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的　合成扎托洛芬。方法　以邻氯苯乙酮为原料制备 10 ,11-二氢二苯并 [b ,f]硫杂 艹卓 - 10 -酮 ,经Friedel-Crafts等八步反应制得扎托洛芬。结果　总收率 9.3%。结论　该方法可用来制备扎托洛芬。OBJECTIVE To synthesize Zaltoprofen.METHODS It was synthesized from 2-chloroacetophenone to 10,11-dihydrodibenzothiepin-10-ketone,via eight steps including Friedel-Crafts reaction.RESULTS The total yield is 9.3% with good quality.CONCLUSION Zaltoprofen can be synthesized by the procedures.

关 键 词：扎托洛芬 非甾体抗炎药 合成方法 邻氯苯乙酮 

分 类 号：R971.1[医药卫生—药品] R914.2[医药卫生—药学]