胃肠道肿瘤病人围手术期细胞因子及蛋白质代谢的变化  

Changes in serum cytokine and protein metabolism in patients with gastroenteric carcinoma during peri-operational period

作　　者：罗世成[1] 胡瑞祥[1] 章时彦[1] 朱军[1] 郭建辉[1] 

机构地区：[1]云南省第一人民医院普外科,云南昆明650032

出　　处：《肠外与肠内营养》2003年第2期82-83,共2页Parenteral & Enteral Nutrition

摘　　要：目的 :探讨胃肠道肿瘤病人手术后肿瘤坏死因子 α (TNF α)、白介素 6 (IL 6 )、白介素 10 (IL 10 )的变化以及与蛋白质代谢的关系。　方法 :用酶联免疫法 (ELISA)检测 19例胃肠道肿瘤根治术病人术前和术后 1、3、5天血清TNF α、IL 6和IL 10水平 ,同时检测蛋白质分解代谢相关指标、2 4h尿中尿素和肌酐排泄量。　结果 :胃肠道肿瘤根治术后病人TNF α呈下降趋势 ,术后第 1天较术前明显下降 (P <0 .0 5 )。IL 6和IL 10术后升高 (P <0 .0 1) ,尤以术后第 1天升高明显。术后 2 4h尿中尿素和肌酐排泄量明显升高。　结论 :胃肠道肿瘤根治术后病人IL 6和IL 10的升高支持手术应激导致的细胞因子释放变化 ,但TNF α呈下降趋势 ,可能与胃肠道肿瘤病人术前TNF α的高表达有关。术后蛋白质分解代谢增加 ,可能与细胞因子IL 6和IL 10的升高有关。Objectives: To investigate the changes of serum cytokines tumor, necrosis factor α(TNF α), interleukin 6 (IL 6), interleukin 10(IL 10) and the protein metabolism in the patients with gastroenteric carcinoma after surgery. Methods: Nineteen patients with gastroenteric cancer who had received radical resection were investigated. The concentrations of TNF α, IL 6 and IL 10 in serum were measured with ELISA before and after operation. At the same time, urine excretion of urea and creatinine was examined. Results: The concentrations of TNF α in serum decreased on the 1st day after operation ( P <0.05). IL 6 and IL 10 increased after operation.The excretion of urea and urea creatinine increased after operation. Conclusions: The serum concentrations of IL 6 and IL 10 increase after operation,with significant increases of urine excretion of urea and creatinine in patients with gastrointestinal cancer.

关 键 词：细胞因子 蛋白质代谢 胃肠道肿瘤 围手术期 

分 类 号：R735[医药卫生—肿瘤]