120例结直肠癌手术前后血清CEA RIA测定的临床观察  

Clinical Investigation of Serum CEA in 120 Patients with Colorectal Cancer

作　　者：李雨升[1] 杨立廷[1] 余云云[1] 于素清[1] 马淑芹[1] 

机构地区：[1]青岛大学医学院附属医院放免中心,山东青岛266003

出　　处：《标记免疫分析与临床》2003年第1期9-11,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为了解结直肠癌患者血清中CEA的水平与该疾病的关系 ,采用RIA法对 12 0例结直肠癌患者手术前后的血清进行了CEA检测 ,同时检测了 2 4名正常人作为对照。结果显示 :正常组CEA为 9.84± 2 .4 4ng/mL ,术前患病组CEA为 38.85± 19.2 1ng/mL ,其中结肠癌组为 37.4 3± 18.5 8ng/mL ,直肠癌组为 39.72± 2 0 .6 7ng/mL ,正常组与患病组比较P <0 .0 1,结肠癌组与直肠癌组比较P >0 .0 5。术后 2个月内对 4 4例术前CEA阳性者进行监测 ,37例CEA降至 11.2 1± 3.6 5ng/mL ,7例因手术无法根治 ,CEA为 5 0 .6 3± 2 4 .38ng/mL。术后长达 6年随访监测有 4 1例复发 ,CEA水平为 4 3.12± 2 7.15ng/mL ,4 1例复发患者中 3年内复发率占 87.80 %。结论 :CEA水平检测对结直肠癌患者术前诊断 ,术后疗效评估及监测肿瘤复发与转移是一种简便易行的有效手段。To investigate the correlation between serum CEA and colorectal cancer, the pre-and postoperative serum CEA in 120 patients with colorectal cancer was measured by RIA,with other 24 cases of healthy donors as control. The results showed that serum CEA in control group and patient group were 9.84± 2.44mg/mL, 38,85±19.21mg/mL respectively, while colonic cancer group 37.43±18.58ng/mL, rectal cancer group 39.72±20.67ng/mL. There was significant difference between patient group and control group ( P <0.01), with no difference between colonic cancer group and rectal cancer group ( P >0.05).Serum CEA of 37 among 44 cases with positive CEA findings decreased to 11.21±3.65ng/mL during two months follow-up post-operation, whereas 50.63±24.38ng/mL in 7/44 cases undergoing non-radical operation. The serum CEA of 41 recurrence cases was 43.12±17.15ng/mL at six-year post-operation, with 87.80% of three-year recurrence rate. It suggested that the serum CEA test is a convenient method for colorectal cancer to preoperatively diagnose it, evaluate postoperative curative effect and detect tumor recurrence and metastasis.

关 键 词：结直肠癌 手术前后 血清 CEA RIA 放射免疫分析 

分 类 号：R735.3[医药卫生—肿瘤]