小儿病毒性脑膜炎病原诊断与临床分析  

Early diagnosis and clinical analysis of the acute viral meningitis in children

作　　者：金玉[1] 余唯琪[1] 薛君莉[1] 李宇宁[1] 林丽星[1] 

机构地区：[1]兰州医学院第一附属医院儿科,甘肃兰州730000

出　　处：《临床儿科杂志》2003年第3期149-151,155,共4页Journal of Clinical Pediatrics

基　　金：甘肃省自然科学基金资助 (ZR_96_080)

摘　　要：应用酶联免疫吸附 (ELISA)方法 ,对88例临床诊断病毒性脑膜炎患儿急性期及恢复期脑脊液进行了单纯疱疹病毒(HSV_Ⅰ、HSV_Ⅱ )、柯萨奇B组病毒 (CoxBV)、埃可病毒 (ECHO)、EB病毒 (EBV)、腺病毒 (AdV)及流感病毒 (IFV)特异性IgM抗体检测。结果表明 :HSV、CoxBV、ECHO、EBV、AdV、IFV病毒感染率分别为9.09 %、18.18 %、22.72%、3.41%、4.54 %5.68% ;HSV及EBV感染致残率及病死率分别为87.5 % (7/8)和100 % (3/3)。提示脑脊液中病毒特异性IgM抗体检测可作为早期病原诊断的指标之一 ;CoxBV及ECHO病毒是本地区小儿中枢神经系统病毒感染的主要病毒 ;HSV及EBV感染致残率及病死率较其它病毒高 ,预后不良 ;早期阿昔洛韦治疗 。To study the early diagnosis and clinical characteristics of viral meningitis in children,the specific IgM antibodies of herpes simplex viruses types1and2(HSV_Ⅰ,HSV_Ⅱ),coxsackieviruses B(CoxBV),echoviruses(ECHO),Epstein_Barr viruses(EBV),adenovirus(AdV)and influenza viruses(IFV)were determined with enzyme_linked imˉmunosorbent assay(ELISA)in the cerebrospinal fluid(CSF)from88viral meningitis cases.The results showed that specific IgM antibodies to HSV,CoxBV,ECHO,EBV,AdV and IFV were positive in9.09%(8/88),18.18%(16/88),22.72%(20/88),3.41%(3/88),4.54%(4/88)and5.68%(5/88)cases,respectively.The rate of infection was45.52%(56/123). Therefore,the detections of specific IgM antibodies is one of the ways to make early diagnosis of viral meningitis.The CoxBV and ECHO were main viruses in the children with acute central nervous system infection in local area.The morbidity and mortality rates of HSV and EBV were87.5%(7/8)and100%(3/3)separately,and were higher than that of other viruses.The early identification of pathogen will be helpful to guide the treatment and improve the prognosis.

关 键 词：病毒性脑膜炎 早期诊断 儿童 

分 类 号：R725.1[医药卫生—儿科]