Fas和FasL在多发性硬化患者表达的意义  

Expressions of Fas and FasL in patients with multiple sclerosis

作　　者：谭清华[1] 赵忠新[1] 张玲珍[2] 

机构地区：[1]第二军医大学长征医院神经内科 [2]第二军医大学长征医院实验科海,上海200003

出　　处：《中华神经科杂志》2003年第1期14-16,共3页Chinese Journal of Neurology

摘　　要：目的　探讨多发性硬化 (MS)患者外周血淋巴细胞Fas和FasL的表达及其与病情严重程度的关系。方法　采用流式细胞术 (FCM)检测 2 2例复发缓解型MS患者外周血淋巴细胞Fas和FasL的表达情况 ,并选择 1 6例同期住院的非免疫相关性疾病患者作为对照。结果　 (1 )复发期MS患者Fas表达 (1 8 2 5 %± 1 0 69% )均高于缓解期MS患者和对照组 (分别为 1 1 43 %± 6 83 % ,9 68%±5 2 4 % ) ;复发期MS患者FasL表达 (2 79%± 2 47% )亦均高于缓解期MS患者和对照组 (分别为1 0 6 %± 0 58% ,0 76 %± 0 61 % )。 (2 )病损程度为重度的MS患者Fas和FasL的表达 (分别为2 1 63 %± 1 2 74% ,3 51 %± 2 0 6 % )均高于中度的MS患者 (分别为 1 2 82 %± 6 1 5 % ,1 94%±1 1 3 % )。 (3)反复发病的MS患者Fas和FasL的表达 (分别为 1 9 56 %± 8 78% ,3 2 8%± 1 82 % )均高于首次发病的MS患者 (分别为 1 3 63 %± 5 36 % ,2 0 6 %± 0 68% )。 (4)MS患者Fas与FasL表达之间呈正相关 (r=0 51 8,P =0 0 0 3)。结论　Fas和FasL与MS的临床复发、复发次数和病情的严重程度有关 ;Objective To investigate the changes of Fas and FasL on lymphocyte in peripheral blood in patient with multiple sclerosis (MS), and relation to the disease severity Methods The expressions of Fas, FasL on lymphocyte in peripheral blood were measured by immunofluorescence phenotyping and flow cytometry from 22 patients with relapsing remitting MS Results The expression of Fas (18.25%±10.69%) in relapsing MS group was higher than the remission (11.43%±6.83%) and the control (9.68%±5.24%) groups shown; While of FasL (2.79%±2.47%) was higher than the remission (1.06%±0.58%) and the control (0.76%±0.61%) groups.The degree of increase was related to the severity of disease and its relapsing time There was shown positive association between Fas and FasL ( P =0 003) Conclusions Fas and FasL should be related to clinical relapsing and relapsing time and disease severity in patients with MS; and Fas and FasL might be involved in the pathogenesis of MS

关 键 词：多发性硬化 流式细胞术 淋巴细胞 CD95抗原 膜糖蛋白类 

分 类 号：R744.51[医药卫生—神经病学与精神病学]