多发性硬化周围神经损伤的病理与临床分析  

Pathological and clinical analysis of peripheral nerve’s injury in patient with multiple sclerosis

作　　者：李润今[1] 郭力军[1] 马翔凌[1] 陈萍[1] 季雪莲[1] 钱志敏[2] 

机构地区：[1]内蒙古自治区医院神经内科,呼和浩特市010017 [2]内蒙古自治区医院眼科,呼和浩特市010017

出　　处：《中华神经科杂志》2003年第1期25-27,共3页Chinese Journal of Neurology

摘　　要：目的　报道 1 2例多发性硬化 (MS)患者周围神经病理检查的异常改变 ,从中证实MS患者存在周围神经的节段性脱髓鞘病损。方法　 1 2例经肌电图检查发现存在周围神经异常改变的患者行腓肠神经活检及病理学观察。结果　 1 1例标本形态上以脱髓鞘为主 ,8例可见有髓纤维减少。电镜下显示髓鞘脱失 ,有髓纤维再生、形成空泡 ;神经膜细胞增生形成葱头样改变 ;7例可见髓鞘板层松解现象。结论　MS患者不但出现CNS的脱髓鞘病损 ,而且部分患者同时存在周围神经系统的脱髓鞘病损。Objective To analyse the pathological features in 12 patients demonstrated with demyelination lesions of peripheral nerves Methods Twelve abnormaly cases were screened with EMG from 60 cases of multiple sclerosis (MS) Sural nerve biopsy was done in 12 patients and specimens were analyzed by HE and Loyez,and by electronic microscopy Results Myelinated fibers was reduced in sural nerve biopsy in 8 cases and most striking demyelination seen in 11 cases In electronic microscopy,11 cases specimens were shown myelinated losses,regeneration of myelinated fibers,vacuoate,hyperplasia of Schwann cell and typical onion bulb formation 8 cases of the large thickened fibers showed increased members of myelin lamellae Conclusion MS is charaterized by inflammatory demyelinating disorder limited to the CNS And some patients' peripheral neves are also shown sectionally demyelinated injury.

关 键 词：多发性硬化 周围神经系统疾病 病理 临床分析 

分 类 号：R744.51[医药卫生—神经病学与精神病学]