谷氨酸转运体与神经退行性疾病  

Glutamate transporter and neurodegenerative disorders

作　　者：杨彦玲[1] 

机构地区：[1]南京医科大学药理学与神经生物学系

出　　处：《中国临床药理学与治疗学》2003年第2期227-231,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助项目 (№ 39970 846)

摘　　要：谷氨酸是哺乳动物脑内最主要的兴奋性神经递质 ,其主要灭活方式是依赖谷氨酸转运体的摄取进入细胞。当谷氨酸转运体失表达、停止转运或反向释放谷氨酸时 ,引起突触间隙或胞外谷氨酸大量蓄积从而导致神经毒性反应。研究表明 ,谷氨酸转运体的摄取功能障碍与肌萎缩性侧索硬化症 (amyo trophiclateralsclerosis ,ALS)、阿尔茨海默病 (Alzhei mer’sdisease ,AD)、帕金森病 (Parkinson’sdisease ,PD)等许多神经退行性病变有关 。Glutamate is the primary excitatory amino acid in the mammal brain. Glutamate transporters perform the regulation of glutamate levels in synaptic cleft. If the glutamate transporters should not be expressed, stopped working, or gone into reverse releasing glutamate from the cytoplasm, there would be an extracellular build up of glutamate. Defective glutamate uptake has been suggested to be important in connection with amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease.

关 键 词：药理学 综述 谷氨酸转运体 肌萎缩性侧索硬化症 阿尔茨海默病 帕金森病 

分 类 号：R741.05[医药卫生—神经病学与精神病学] R977.4[医药卫生—临床医学]