血清β_2-微球蛋白测定在消化系统疾病中的应用价值  

The Value of Measurement of Serum β_2-Microglobulin in Diagnosis of Digestive Diseases

作　　者：林学壬[1] 邓永坚[1] 徐立[1] 

机构地区：[1]暨南大学医学院第五附属医院(广东省清远市人民医院)消化内科,511500

出　　处：《中国误诊学杂志》2003年第1期27-29,共3页Chinese Journal of Misdiagnostics

摘　　要：目的　探讨血清 β2 -微球蛋白 (β2 - Microglobulin,β2 - MG)在消化系统疾病中的变化水平和诊断价值。方法　采用放射免疫分析法检测 112例消化系统恶性肿瘤和 173例消化系统良性疾病患者和 6 0例正常人的血清 β2 - MG水平。结果　消化系统恶性肿瘤比消化系统良性疾病和正常人的血清 β2 - MG明显增高 (P<0 .0 1) ;高 β2 - MG血症发生率消化系统恶性肿瘤 (6 3.39% )较良性疾病 (16 .76 % )明显增高 (P<0 .0 1) ;血清β2 - MG增高在进展期肿瘤中占 92 .86 % ,相对稳定期肿瘤中仅占 5 3.5 7% (P<0 .0 1)。结论　血清β2 - MG有助于鉴别消化系统良、恶性疾病 ,而动态观察肿瘤患者的血清 β2 - MG变化对判断病程进展、评价预后有一定的临床实用价值。Objective To explore the diagnostical value and change of serumβ 2 microglobulin in digestive diseases.Methods With radioimmunoassay,serumβ 2 microglobulins were measured in 112 patients with malignant digestive diseases and 173 patients with benign digestive disease and 60 healthy persons.Results Serumβ 2 microglobulin level was significantly higher in malignant digestive diseases than in benign digestive diseaseand healthy persons.(P<0.01).High serum β 2 microglobulin was seen more often in malignant digestive diseases than in benign digestive disease (63.39% vs 16.76%,P<0.01).High serum β 2 microglobulin was seen in 92.86% of patients with advanced stage and 53.57% of patients with relatively stable stage(P<0.01),respectively.Conclusion Measurement of serumβ 2 microglobulin should be helpful to differentiate the benign and malignant digestive diseases,and dynamic observation of serum β 2 microglobulin level could play and important role in assessing the development of diseases and prognosis.

关 键 词：Β2-微球蛋白 消化系统疾病 诊断 放射免疫检测 

分 类 号：R57[医药卫生—消化系统]