α-L-岩藻糖苷酶对原发性肝癌诊断价值的探讨  

Study on the diagnostic value of α- L - iucosidase on primary hepatic carcinoma.

作　　者：赵平[1] 王江滨[1] 张爱国[1] 王广[1] 

机构地区：[1]中日联谊医院消化内科,长春130031

出　　处：《临床肝胆病杂志》2003年第2期109-110,共2页Journal of Clinical Hepatology

摘　　要：探讨α-L-岩藻糖苷酶(alpha-L-fucosidase AFU)对原发性肝癌的诊断价值。分别采用放免法和显色多肽基质法对93例原发性肝癌、45例恶性肿瘤、98例良性肝病、46名孕产妇及20例正常健康人的血清甲胎蛋白(alpha-fetoprotein AFP)水平和AFU活性进行联合检测。原发性肝癌组血清AFP水平及AFU活性明显高于其它各疾病组。AFU和AFP对原发性肝癌诊断的敏感性分别为76.3％和74.2％,在AFP阴性肝癌患者中AFU阳性率为75.0％。AFU、AFP两者联合检测诊断原发性肝癌的敏感性可提高到93.5％。To discuss the diagnostic value of a - L - fucosidase on primary hepatic carcinoma. Serum levels between AFU and AFP were measured in patients with PHC (93 cases) , malignant tumor (45 cases) , benign liver disease (98 cases) , gravida and puer-perant (46 cases) and healthy (20 cases) . The levels of AFU and AFP in PHC groups was significant different from other groups. The sensitivity of AFU and AFP is 76.3% and 74.2% ,The positive rate of AFU in AFP - negative PHC group is 75.0% . The sensitivity can be increased to 93.0% when AFU and AFP were combining detected.

关 键 词：Α-L-岩藻糖苷酶 甲胎蛋白 原发性肝癌 肝硬化 

分 类 号：R735.7[医药卫生—肿瘤]