PCNA,MMP-9预计肝细胞肝癌预后的研究分析  

To study Itae relationship between the expression of proliferating cell nuclear antigen (PCNA) and matrix metallopro- teinase - 9(MMP- 9) and the prognosis of hepatocellular cancer

作　　者：张勤[1] 张文[1] 

机构地区：[1]天津第三中心医院病理科,天津市300170

出　　处：《临床肝胆病杂志》2003年第2期113-114,共2页Journal of Clinical Hepatology

摘　　要：探讨增殖细胞核抗原(PCNA)基质金属蛋白酶(MMP-9)与肝细胞肝癌预后的关系。应用S-P法,对44例患者分别进行PCNA、MMP-9两种免疫组化染色,并对结果进行统计学处理。1.PCNA染色中,(-)～(+)组预后好于(++)～(+++)组(x^2=5.13,P<0.05)。2.MMP-9染色中,癌组织(-)组预后好于(+)组(x^2=4.51,P<0.05);癌旁组织(+)组预后好于(-)组(x^2=4.47,P<0.05)。在术后生存时间<1年的患者的肿瘤细胞中PCNA高表达,说明肝细胞的增殖程度较高。<1年的患者的癌组织中,MMP-9亦高表达,说明肝细胞侵袭力较高;而癌旁组织中MMP-9却低表达,说明宿主的免疫力较低。因此二者均可作为预计肝细胞肝癌预后的指标。44 patients were blotted by PCNA and MMP - 9 with S - P reagents. The results was analyzed by statistics. 1. In PCNA blotting, the prognosis of ( - )- ( + )group was significantly better than the (++)-(+++ )group. ( x2 = 5.13, P < 0.05). 2. In MMP -9 blotting, the prognosis of (-) group was better than( + )group in tumor tissue {x2 = 4.51, P < 0.05); The prognosis of ( + )group was better than ( - ) group in nontumorous liver tissues. ( x2 = 4.47, P < 0.05). In the patients with the peroid of survival less than one year, the expression of PCNA was high in tumor tissue. This related with the higher prolifera-tive degree in tumor cell. And the same in MMP- 9 blotting, it was proved that the power of invasion was higher in tumor cell too. But in nontumorous liver tissue, the expression of MMP- 9 was low. And this related with the lower immunity of host, so both of PCNA and MMP - 9 may be markers in evaluating the prognosis of HCC.

关 键 词：肝细胞肝癌 预后 基质金属蛋白酶 增殖细胞核抗原 

分 类 号：R735.7[医药卫生—肿瘤]