血清纤维化指标与慢性肝病的关系  

A Study on the Relationship Between Serum Markers for Fibrosis and Chronic Liver Diseases

作　　者：徐章[1] 杜亚平[1] 胡阳黔[1] 黄晓东[1] 姜红梅[1] 王子强[1] 贾国凤[1] 李金范[1] 李树人[1] 张兵[1] 

机构地区：[1]郧阳医学院东风临床学院,东汽公司中心医院十堰442008

出　　处：《临床消化病杂志》2003年第2期62-64,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的:探讨血清纤维化指标透明质酸(HA)、层粘蛋白(LN)和Ⅲ型前胶原(PCⅢ)水平与慢性肝病的关系。方法:用放射免疫法测定96例慢性肝病患者血清HA、LN和PCⅢ水平,同时行肝组织活检,对肝组织进行炎症分级和纤维化分期。分析血清纤维化指标水平与肝组织分级和分期间的关系。结果:血清HA、LN和PCⅢ水平随慢性肝病的进展均逐渐升高,在慢性重度肝炎和肝硬化时达高峰,与肝组织炎症坏死和纤维化程度呈正相关。结论:血清HA、LN和PCⅢ水平可作为肝纤维化程度的指标之一。Purpose: To investigate the relationship between serum levels of hyaluronic acid(HA) , laminin(LN), type Ⅲ procollagen(PC Ⅲ ) and chronic liver diseases. Methods: These 3 serum components were measured in 96 patients with chronic liver diseases by radioimmunoassay. Liver biopsy as well as serum HA, LN and PC Ⅲ detection were performed at the same time in all patients, the results of which were compared with hepatic histological findings diagnosed by the standard of hepatic histological grade and stage. Results: Serum conentration of HA, LN and PC Ⅲ were increased with the progression of disease, and reached the highest levels in chronic severe hepatitis and liver cirrhosis. These serum components were positively correlated with inflammation activity and fibrosis of liver. Conclusion: The results suggest that determination of serum HA, LN and PC Ⅲ may be of value in diagnosing hepatic fibrosis.

关 键 词：慢性肝病 透明质酸 层粘蛋白 Ⅲ型前胶原 肝硬化 血清 

分 类 号：R575[医药卫生—消化系统]