动脉粥样硬化性脑梗塞和脑出血患者血浆可溶性血栓调节蛋白水平的研究  

Plasma Levels of Thrombomodulin in Patients with Atherothrombotic Cerebral Infarction and Cerebral Hemorrhage

作　　者：刘建仁[1] 章昀[1] 张敏 张佩利[1] 黄鉴政[1] 魏尔清[3] 

机构地区：[1]浙江大学医学院附属第二医院神经内科,浙江杭州310009 [2]武警杭州医院内科,浙江杭州310050 [3]浙江大学医学院神经生物学实验室,浙江杭州310009

出　　处：《科技通报》2003年第2期158-161,共4页Bulletin of Science and Technology

摘　　要：目的探讨血浆可溶性血栓调节蛋白(Solublethrombmodulin,sTM)与脑梗塞和脑出血患者小血管损伤、动脉粥样硬化的关系.方法应用酶联免疫吸附方法(Enzyme-LinkedImmunosorbentAssays,ELISA),检测60例脑梗塞患者、56例脑出血患者和64例健康对照的sTM水平,并分析sTM与血脂、血压的关系.结果脑梗塞和脑出血的甘油三脂、舒张期血压明显高于对照组;脑梗塞和脑出血的高密度脂蛋白显著低于对照组;脑出血组的收缩期血压明显高于其他两组;脑梗塞的总胆固醇水平显著高于其他两组;脑出血的sTM显著高于脑梗塞和对照组,而脑梗塞的sTM显著高于对照组.sTM与总胆固醇、甘油三脂、收缩和舒张期血压水平显著正相关;sTM与高密度脂蛋白水平成显著负相关.结论脑梗塞和脑出血患者的高水平的sTM提示脑梗塞和脑出血存在由高血压和动脉粥样硬化导致的小血管损伤.sTM是脑卒中的独立危险因子.Objective To elucidate relationship between plasma soluble thrombomodulin (sTM) and small vascular injury and atherothrombosis in patients with atherothrombotic cerebral infarction and cerebral hemorrhage. Methods Plasma sTM was detected by ELISA in 60 patients with cerebral infarction, 56 patients with cerebral hemorrhage and 64 healthy controls. Relationships between sTM and blood lipids/blood pressure were analyzed. Results Levels of triglyceride and systolic blood pressure in patients with cerebral infarction and cerebral hemorrhage were higher than those of the control group. Level of high density lipoprotein of cerebral infarction and cerebral hemorrhage was higher than that of the control group. Level of total cholesterol in cerebral infarction was higher than that of other two groups. Level of sTM in patients with cerebral hemorrhage was higher than that of the other two groups. Level of sTM in patients with cerebral infarction was higher than that of the control. Level of sTM was significantly positively correlated with that of total cholesterol, trigliceride and systolic blood pressure. Level of sTM was significantly negatively correlated with that of high density lipoprotein.Conclusion High plasma sTM in patients with cerebral infarction and cerebral hemorrhage indicates small vascular injury caused by atherothrombosis and higher blood pressure. sTM is an independent risk factor of cerebral stroke. 

关 键 词：神经病学 脑梗塞 脑出血 血浆可溶性血栓调节蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]