高湿环境对大鼠血液流变学、一氧化氮及内皮素的影响  

Effect of High Humidity Environment on Hemorrheology, Nitric Oxide and Endothelin in Rats

作　　者：秦鉴[1] 金明华[1] 吴国珍[1] 刘红健[1] 张诗军[1] 朱雅宜[1] 罗致强[1] 

机构地区：[1]中山大学附属第一医院,广州510080

出　　处：《中国中西医结合杂志》2003年第3期211-212,共2页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家教育部博士点基金(No.1999056907)广东省中医药管理局科研基金(No.99571)联合资助

摘　　要：目的:探讨高湿环境对大鼠血液流变学的影响。方法:取SD大鼠分为3组,在高湿环境中处理5、10、15天,观察不同处理时间大鼠血液流变学各指标、一氧化氮(NO)及内皮素(ET)水平变化。结果:高湿环境会导致大鼠血液流变学各指标增高,NO水平下降,ET水平上升,且变化幅度随时间延长而增加。结论:高湿环境可以导致血瘀证相关指标的变化,为因湿致瘀的假说提供了初步的实验依据。Objective: To find out the mechanism of exogenous humidity in inducing blood stasis. Methods: SD rats were divided into 3 groups, they were managed in the environment with high humidity for 5, 10 and 15 days respectively to observe the effect on hemorrheologic criteria, nitric oxide (NO) and endothelin (ET) at different times. Results: High humidity environment could induce the hemorrheologic criteria increased, NO level lowered, ET level raised, and the amplitude of change increased along with the prolonging of action time. Conclusion: High humidity environment could induce changes of the blood stasis related criteria, which provides a preliminary experimental basis for the hypothesis of 'Dampness caused blood stasis

关 键 词：高湿环境 血瘀证 因湿致瘀 血液流变学 一氧化氮 内皮素 ET NO 

分 类 号：R228[医药卫生—中医基础理论]